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聚吡咯/碳纳米管分子印迹修饰电极对槲皮素的选择性测定
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作者单位
朱玲艳,王宗花,陈小印,张菲菲,夏延致,李延辉 青岛大学纤维新材料与现代纺织实验室国家重点实验室培育基地 
基金项目:国家自然科学基金资助项目(20975056,50802045);青岛市科技计划基础研究项目(091330jch);山东省泰山学者资助项目(TS20070711)
中文摘要:制备了一种新颖的可对槲皮素分子进行选择性测定的分子印迹聚合物膜修饰电极。在碳纳米管(CNT)独特的结构和力学性能作用下,以吡咯(Py)为功能单体,槲皮素为模板分子,电聚合方法制备了槲皮素的分子印迹聚合物膜修饰电极(PPy/CNT/GCEMIP)。用电化学交流阻抗法研究了该修饰电极的界面性质,用循环伏安法和差分脉冲伏安法研究了槲皮素在修饰电极上的电化学行为。实验表明,该修饰电极能显著提高槲皮素的氧化峰电流,降低其氧化峰电位,并可在与其结构相似的桑色素等黄酮类物质的存在下,实现对槲皮素的选择性测定。在磷酸盐缓冲液(pH 70)中,槲皮素的浓度在10×10-7 ~ 10×10-3 mol/L范围内,其氧化峰电流与浓度存在良好的线性关系,检出限为55×10-8 mol/L。该修饰电极可用于含槲皮素成分药物的直接测定。
中文关键词:碳纳米管  分子印迹聚合物  槲皮素  桑色素  选择性
 
olecularly Imprinted Polymer Incorporated Carbon Nanotube Modified Electrode for Selective Determination of Quercetin
Abstract:A molecularly imprinted polymer membrane modified electrode(PPy/CNT/GCEMIP) was developed via the electrochemical polymerization of pyrrole in the presence of carbon nanotube and the molecular template quercetin(Qu).The electrochemical performance of PPy/CNT/GCEMIP was studied by electrochemical impedance spectroscopy(EIS).The electrochemical behaviors of Qu were investigated with cyclic voltammetry(CV) and differential pulse voltammetry(DPV) at the PPy/CNT/GCEMIP.The results showed that a sensitive oxidation peak was observed at 0184 V in pH 70 PBS and the peak current was improved obviously,indicating that PPy/CNT/GCEMIP exhibited good electrocatalytic activity and enrichment towards Qu.Meanwhile,the PPy/CNT/GCEMIP displayed a high selectivity in voltammetric measurements of Qu in the presence of morin with an anodic peak separation value of 263 mV by DPV.Under the optimal conditions,the oxidation peak current of Qu at the modified electrode was linear with the concentration over the range of 10 × 10-7-10 × 10-3 mol/L with a detection limit of 55 × 10-8 mol/L.The relative standard deviation(RSD,n=5) for 10 × 10-4 mol/L Qu was 02% .With good stability,high selectivity,and wide linear range for the determination of Qu,PPy/CNT/GCEMIP could be applied in the determination of tablets containing Qu.
Key Words:carbon nanotube  molecularly imprinted polymer  quercetin  morin  selectivity
引用本文:朱玲艳,王宗花,陈小印,张菲菲,夏延致,李延辉.聚吡咯/碳纳米管分子印迹修饰电极对槲皮素的选择性测定[J].分析测试学报,2011,30(1):18-23.
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