| 流动注射化学发光法测定利福喷丁 |
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| 基金项目:陕西省高水平大学建设专项资金(2013SXTS03)；陕西省重大基础研究项目(2016ZDJC-19)；延安市科技创新团队项目(2015CHTD-04) |
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| 中文摘要:基于碱性介质中利福喷丁能增敏鲁米诺-铁氰化钾体系的化学发光这一现象，结合流动注射分析技术，建立了流动注射化学发光法测定利福喷丁的新方法。在最佳实验条件下，利福喷丁检测浓度的线性范围为0.008~0.88 mg/L，检出限(3σ)为1.2×10-3 mg/L。对6.0×10-2 mg/L的利福喷丁进行平行测定，其相对标准偏差(RSD，n=11)为1.9%。该方法已用于测定胶囊和血浆中利福喷丁的含量，结果满意。 |
| 中文关键词:流动注射 化学发光 鲁米诺 铁氰化钾 利福喷丁 |
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| Determination of Rifapentine by Flow Injection Chemiluminescence Method |
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| Abstract:A novel method of flow injection chemiluminescence for the determination of rifapentine was proposed based on the phenomenon that the chemiluminescence intensity of the luminol-K3Fe(CN)6 system could be enhanced by rifapentine in alkaline medium,combined with flow injection analysis technique.Under the optimal experimental conditions,the linear range of rifapentine’s detection concentration was 0.008-0.88 mg/L,the detection limit(3σ) was 1.2×10-3 mg/L,and the relative standard deviation(RSD,n=11) was 1.9% for rifapentine at 6.0×10-2 mg/L.The method was applied in the determination of rifapentine in both capsules and plasma with satisfactory results. |
| Key Words:flow injection chemiluminescence luminol potassium ferricyanide rifapentine |
| 引用本文：徐通，张琰图，张绪.流动注射化学发光法测定利福喷丁[J].分析测试学报,2017,36(6):805-808. |
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