| 高效液相色谱-电感耦合等离子体质谱法测定化妆品中2-溴-2-硝基-1，3-丙二醇 |
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| 基金项目:中国食品药品检定研究院“化妆品中防腐剂的检验方法研究(2015-2016)”项目 |
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| 中文摘要:建立了高效液相色谱-电感耦合等离子体质谱(HPLC-ICP-MS)测定化妆品中2-溴-2-硝基-1，3-丙二醇的方法。采用ZORBAX RX-C8色谱柱(150×2.1 mm，5 μm)进行分离，以甲醇-水-5%磷酸(10∶985∶5， 用2 mol/L NaOH调至pH 3.0)为流动相，流速为0.7 mL/min，柱温为室温。结果显示，2-溴-2-硝基-1，3-丙二醇在2.5 min处出峰，其线性范围为0.01 ~1.0 mg/L，相关系数为 0.999 9。不同基质化妆品的方法检出限均为1.0 μg/g，回收率为94.6% ~ 101.3%，相对标准偏差(RSD，n=6)为1.5% ~4.5%。该方法快速、准确、灵敏、无干扰，适用于化妆品中2-溴-2-硝基-1，3-丙二醇的定性定量测定。 |
| 中文关键词:高效液相色谱(HPLC) 电感耦合等离子体质谱(ICP-MS) 2-溴-2-硝基-1，3-丙二醇 化妆品 |
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| Determination of 2-Bromo-2-nitro-1，3-propanediol in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry |
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| Abstract:A new method was established to determine 2-bromo-2-nitro-1，3-propanediol in cosmetics by high performance liquid chromatography-inductively coupled plasma mass spectrometry(HPLC-ICP-MS). The analyte was separated on a ZORBAX-C8 column (150×2.1 mm， 5 μm) using methanol-water-5% phosphoric acid (10 ∶ 985 ∶ 5， pH value was adjusted to 3.0 with 2 mol/L NaOH) as mobile phase. The flow rate was set at 0.7 mL/min. The column temperature was room temperature. The results indicated that the calibration curve of 2-bromo-2-nitro-1，3-propanediol was linear in the range of 0.01-1.0 mg/L，with a correlation coefficient(r) of 0.999 9. The detection limits of different matrix samples were all 1.0 μg/g. The spiked recoveries of 2-bromo-2-nitro-1，3-propanediol ranged from 94.6% to 101.3%， with RSDs(n=6) of 1.5%- 4.5%. The method showed the advantages of rapidness，sensitivity，accuracy and little interference，and it could be used for the qualitative and quantitative determination of 2-bromo-2-nitro-1，3-propanediol in cosmetics. |
| Key Words:high performance liquid chromatography(HPLC) inductively coupled plasma mass spectrometry(ICP-MS) 2-bromo-2-nitro-1,3-propanediol cosmetics |
| 引用本文：王枚博，钟吉强，陈丹丹，毛北萍，王欣美，郑荣，刘畅，王柯.高效液相色谱-电感耦合等离子体质谱法测定化妆品中2-溴-2-硝基-1，3-丙二醇[J].分析测试学报,2017,36(7):925-928. |
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