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高效液相色谱-串联质谱法测定食品接触材料及制品中27种全氟化合物迁移量
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作者单位
王晶,张子豪,麦晓霞,肖前,翟翠萍,刘莹峰,郑建国,李攻科 1.广东出入境检验检疫局2.中山大学化学与化学工程学院 
基金项目:国家重点研发计划(2016YFF0203705)
中文摘要:建立了食品接触材料迁移模拟环境中27种全氟化合物的高效液相色谱-串联质谱检测方法。选取乙酸(3%)、乙醇(10%、50%)和橄榄油作为食品模拟物,模拟了食品接触材料在与不同类型食物接触下的迁移行为,根据(EU)No10/2011的要求对样品进行处理,每6 dm2食品接触材料加入1 L食品模拟物浸泡。水相模拟物经过滤后直接检测,橄榄油经乙腈提取后进行检测。模拟溶液样品以甲醇-水混合溶液为流动相,经C18色谱柱分离,在MRM模式下进行检测。结果表明:全氟化合物在1~1 000 μg/L质量浓度范围内线性关系良好(r>0999 1);全氟化合物在食物模拟物中的定量下限为028~985 μg/kg;对空白样品进行10、100 ng两个浓度水平的加标回收试验,加标回收率为826%~1121%,相对标准偏差为22%~72%。
中文关键词:食品接触材料  全氟化合物  高效液相色谱-串联质谱  迁移量
 
Determination of the Migration of 27 Perfluorinated Compounds in Food Contact Materials by High Performance Liquid Chromatography-Tandem Mass Spectrometry
Abstract:A high performance liquid chromatography-tandem mass spectrometric(HPLC-MS/MS) method was developed for the determination of the migration of 27 perfluorinated compounds in food contact materials using 3% acetic acid,10% alcohol,50% alcohol and olive oil as food simulants. Samples were soaked in 1 L different kinds of food simulants every 6 dm2 food contact materials according to (EU) No10/2011.The water based simulant samples could be analyzed directly after filteration,and the olive oil stimulant samples should be extracted with acetonitrile before analysis. The simulated solution samples were separated on a C18 column with methanol-water as mobile phase,and analyzed under multiple reaction monitoring(MRM) mode.The results showed that there existed good linearities(r>0999 1) for 27 perfluorinated compounds in the range of 1-1 000 μg/L.The LOQs of PCFs were in the range of 028-985 μg/kg in food simulants.The recoveries for 27 perfluorinated compounds in blank samples at two spiked levels of 10 and 100 ng ranged from 826% to 1121% with relative standard deviations(RSDs) of 22%-75%.
Key Words:food contact materials  perfluorinated compounds  liquid chromatography-tandem mass spectrometry  migration
引用本文:王晶,张子豪,麦晓霞,肖前,翟翠萍,刘莹峰,郑建国,李攻科.高效液相色谱-串联质谱法测定食品接触材料及制品中27种全氟化合物迁移量[J].分析测试学报,2018,37(5):570-575.
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