| 气相色谱-质谱法测定化妆品中8种乙二醇醚类物质 |
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| 基金项目:国家重点研发计划项目(2016YFF0203702) |
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| 中文摘要:建立了化妆品中8种乙二醇醚类物质的气相色谱-质谱分析方法。样品经甲醇超声提取，提取液经045 μm微孔滤膜过滤后，采用气相色谱-质谱法分析，外标法定量。在优化的色谱条件下，8种乙二醇醚类物质可实现基线分离，在各自线性范围内线性良好(r2＞0999)。在005、05、5 mg/kg 3个加标水平下，平均加标回收率为822%~1130%，相对标准偏差(RSD，n=6)为060%~85%。方法的检出限为010~100 mg/kg，定量下限为025~200 mg/kg。该方法操作简便，准确可靠，重现性好，可用于化妆品中乙二醇醚类物质的测定。 |
| 中文关键词:气相色谱-质谱 化妆品 乙二醇醚类物质 |
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| Determination of Eight Ethylene Glycol Ethers in Cosmetics by Gas Chromatography-Mass Spectrometry |
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| Abstract:An effective method was established for the determination of eight ethylene glycol ethers in cosmetics by gas chromatography-mass spectrometry(GC-MS).Samples were ultrasonically extracted with methanol.The extracts were filtered,and analyzed by GC-MS.The quantitation was carried out by the external standard method.The eight target compounds were baseline separated under optimized chromatographic conditions.Good linearities were obtained in respective linear ranges,with correlation coefficients all larger than 0999.The mean recoveries at three spiked levels ranged from 822% to 1130% with relative standard deviations(RSDs) of 060%-85%.The limits of detection(LODs) were in the range of 010-100 mg/kg and the limits of quantitation(LOQs) were 025- 200 mg/kg.The method is simple,accurate,reliable and reproducible,and could be applied in the determination of ethylene glycol ethers in cosmetics. |
| Key Words:gas chromatography-mass spectrometry(GC-MS) cosmetics ethylene glycol ethers |
| 引用本文：陈萌,郭项雨,曾婷婷,李蓉,白桦,吕庆,王鹏龙,雷海民，马强.气相色谱-质谱法测定化妆品中8种乙二醇醚类物质[J].分析测试学报,2018,37(5):576-581. |
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