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离子淌度质谱技术及其应用研究进展
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作者单位
王玉娜,孟宪双,刘丽娟,白桦,马强 1.中国检验检疫科学研究院2.哈尔滨医科大学公共卫生学院 
基金项目:国家重点研发计划(2016YFF0203704)
中文摘要:离子迁移谱是一种以气相离子在电场和气流共同作用下发生迁移时的淌度来表征化合物的技术。离子淌度质谱提供了新一维度的离子淌度分离和测量信息,除按照质荷比区分离子外,还可根据离子尺寸和形状进行分离。其与色谱技术联用,可获取包括保留时间、迁移时间、质荷比和响应强度在内的四维数据,在提高传统质谱数据准确性和特异性的同时,还可计算离子的碰撞横截面积,从而获得样品的结构信息。该文综述了近年来离子淌度质谱技术在公共安全、毒品检测、食品安全、环境监测、药物分析以及生物大分子等领域的研究进展,并对该技术的应用前景和发展趋势进行了展望,以期为相关领域的科技人员提供理论支持和技术参考。
中文关键词:离子迁移谱  离子淌度质谱  综述
 
Research Progress on Ion Mobility Spectrometry-Mass Spectrometry and Its Applications
Abstract:Ion mobility spectrometry(IMS)is a technique characterizing compounds based on the mobility of gas phase ions under the joint influence of electric field and gas flow.Ion mobility spectrometry-mass spectrometry(IMS-MS)combines the advantages of ion mobility separation and mass spectrometry analysis.In addition to differentiation by the mass-to-charge ratio(m/z),the ions can be separated according to their sizes and shapes,thus providing a new dimensional information of mobility based separation and measurement.When coupled with chromatographic technique,IMS-MS can be used to obtain four dimensional data,including retention time,drift time,m/z and signal intensity to improve the analysis accuracy and specificity.The collisional cross section(CCS)of ions can also be calculated to explore the structural information.In this paper,recent advances of IMS-MS in the fields of public security,drug testing,food safety,environmental monitoring,pharmaceuticals analysis and biomacromolecules were reviewed.The trends and prospects for the development of IMS-MS were discussed,which may provide a theoretical support and a technical guidance for the researchers engaged in relevant fields.
Key Words:ion mobility spectrometry(IMS)  ion mobility spectrometry-mass spectrometry(IMS-MS)  review
引用本文:王玉娜,孟宪双,刘丽娟,白桦,马强.离子淌度质谱技术及其应用研究进展[J].分析测试学报,2018,37(10):1130-1138.
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