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聚集诱导发光分子在光动力治疗中的研究进展
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作者单位
许敏,龙资,易小庆,娄筱叮,夏帆 1.中国地质大学(武汉)纳米矿物材料及应用教育部工程研究中心,材料与化学学院2.华中科技大学化学与化工学院 
基金项目:国家自然科学基金资助项目(21525523,21722507,21574048);中国博士后科学基金(2017M612527)
中文摘要:光动力治疗(PDT)已成为治疗癌症的重要方法之一。传统光敏剂由于存在选择性差、易光漂白等问题,极大地限制了其在临床上的应用。而具有聚集诱导发光特性的荧光分子(AIEgens),在光照条件下能产生活性氧,并能够将肿瘤细胞杀死,具有治疗癌症的功效。此外,AIEgens还具有易制备、荧光特性优异、生物相容性好以及被动靶向效应(EPR效应)等优点,已被广泛应用于光动力治疗领域,并取得了巨大的发展,具有潜在的医学应用价值。该文主要概括并讨论了近5年来AIEgens在光动力治疗中的研究进展,并进行了展望。AIEgens将成为临床领域中有前途的光动力治疗材料,有望成为肿瘤患者的福音。
中文关键词:光动力治疗  光敏剂  聚集诱导发光
 
Recent Advances of Aggregation induced Emission in Photodynamic Therapy
Abstract:Photodynamic therapy(PDT)has emerged as one of the important therapeutic options for cancers.However,traditional photosensitizers have some defects such as poor selectivity and low photo-stability,which limit their clinical applications.Fortunately,some fluorescence molecules with aggregation-induced emission(AIEgens)characteristics could be used as a novel photosensitizer.The utilization of AIEgens has recently been developed at a tremendous pace,as compared with other materials,AIEgens possess various distinct advantages such as good biocompatibility,excellent fluorescent properties,simple preparation and modification,perfect size of nanoparticles for enhanced permeability and retention effect,etc.The advantages of AIEgens in PDT are introduced in this review,and the originative studies in PDT based on AIEgens in recent five years are systematically summarized.AIEgens would be a promising multifunctional material in PDT,and facilitate significant advancements in field of cancer therapy.
Key Words:photodynamic therapy  photosensitizer  aggregation induced emission
引用本文:许敏,龙资,易小庆,娄筱叮,夏帆.聚集诱导发光分子在光动力治疗中的研究进展[J].分析测试学报,2018,37(10):1147-1157.
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