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高分辨质谱技术研究DART离子化条件下的背景离子及潜在应用
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作者单位
沙云菲, 谢雯燕, 王昊阳 1.上海烟草集团有限责任公司技术中心2.中国科学院上海有机化学研究所 
基金项目:国家自然科学基金(21772227);上海市科委研究项目(17DZ1205402);中国烟草总公司科技重大专项(中烟办[2016]259号)
中文摘要:运用高分辨质谱技术对实时直接分析(DART)离子化条件下的多种背景离子进行研究和表征,追溯了这些信号可能的来源。研究表明:背景离子主要在阳离子条件下产生,且主要来自实验室环境中微量的增塑剂和聚二甲基硅氧烷,其中聚二甲基硅氧烷可能来自泵油挥发。了解和掌握这些背景离子有助于利用DART技术开展研究和测试方面的工作:①这些背景信号较弱,在DART的样品分析时不会产生显著干扰。可在不额外加入内标化合物的情况下,考察高分辨质谱质量轴的稳定性和准确度。②了解这些背景离子有助于DART质谱分析复杂体系时避免误判。
中文关键词:实时直接分析(DART)  高分辨质谱  背景离子
 
Study on Background Ions under DART Ionization Conditions by High Resolution Mass Spectrometry and Their Potential Applications
Abstract:High resolution mass spectrometry(HRMS)was used to study and characterize the background ions under direct analysis in real time(DART) ionization conditions,and the possible sources of these signals were traced and assigned.The research showed that the background ions are mainly generated under the positive ion mode,which may derive mainly from plasticizers and polydimethylsiloxane in the lab environment.The polydimethylsiloxane may come from the pump oil vapor.Understanding and mastering of these background ions will be favorable in the research and testing by DART-MS technique.Firstly,these background signals are stable and do not produce significant interference in sample analysis of DART.Therefore,the stability and accuracy for HRMS spectrometer could be investigated with no need of any internal standard compounds added deliberately.Secondly,understanding of these background ions will also help to avoid erroneous judgment in DART mass spectrometry analysis on complex systems.
Key Words:direct analysis in real time  high resolution mass spectrometry(MS)  background ions
引用本文:沙云菲, 谢雯燕, 王昊阳.高分辨质谱技术研究DART离子化条件下的背景离子及潜在应用[J].分析测试学报,2018,37(10):1264-1268.
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