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高效液相色谱-质谱联用法快速筛查化妆品中112种禁用药物
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作者单位
陈少波,蒲云月,王海瑞,徐振东 1.苏州检验检疫综合技术中心2.苏州世标检测技术有限公司3.苏州华博日化品检测服务有限公司 
基金项目:国家质量监督检验检疫总局科技计划项目(2016IK142);江苏检验检疫局科技计划项目(2017KJ48)
中文摘要:建立了同时筛查确认化妆品中喹诺酮类、糖皮质激素类、硝基咪唑类、四环素类、大环内酯类、磺胺类、头孢类和性激素8类112种禁用药物的高效液相色谱-质谱联用分析方法。试样采用0.2%甲酸乙腈作为提取液,通过QuEChERS净化后过滤膜上机检测。以0.2%甲酸水-0.2%甲酸乙腈溶液为流动相梯度洗脱,C18色谱柱分离,质谱动态多反应监测(DMRM)模式进行分析。结果表明,112种药物的定量下限为2.0~10.0 μg/kg;加标回收率为82.0%~108%;相对标准偏差(RSD)为2.0%~7.9%。该方法操作简单、快速、高效,适用于化妆品中上述几类禁用药物的快速筛查和测定。
中文关键词:化妆品  禁用药物  高效液相色谱-质谱联用(HPLC-MS/MS)
 
Simultaneous and Rapid Screening of 112 Prohibited Drugs in Cosmetics by High Performance Liquid Chromatography-Tandem Mass Spectrometry
Abstract:An analytical method was established for the simultaneous screening and determination of 112 prohibited drugs,including quinolones,glucocorticoids,nitroimidazoles,tetracyclines,macrolides,sulfonamides,cephems and androgens in cosmetics by high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).The sample was extracted with 0.2% formic acid-acetonitrile,and then purified by QuEChERS method.The extracts were separated on an Agilent ZorbaxEclipsePlus C18(3.0 mm×150 mm,1.8 μm) column with 0.2% formic acid-acetonitrile solution containing 0.2% formic acid as mobile phase by gradient elution,and analyzed by LC-MS/MS under dynamic multiple reaction monitoring(DMRM) mode.Results showed that the limits of quantitation(LOQ,S/N=10) for 112 target compounds in cosmetics were in the range of 2.0-10.0 μg/kg.The mean recoveries for 112 prohibited drugs were in the range of 82.0%-108% with their RSDs of 2.0%-7.9%.The method has the advantages of simplicity,rapidness and high efficiency,and could be applied in the screening and confirmation on 112 prohibited drugs in cosmetics in routine analysis.
Key Words:rapid screening  cosmetics  prohibited drugs  high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)
引用本文:陈少波,蒲云月,王海瑞,徐振东.高效液相色谱-质谱联用法快速筛查化妆品中112种禁用药物[J].分析测试学报,2018,37(11):1302-1310.
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