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离子迁移质谱技术及其在脂质分析中的应用
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作者单位
吴邦富,魏芳,谢亚,徐淑玲,吕昕,陈洪 中国农业科学院油料作物研究所农业部油料加工重点实验室农业部油料作物生物学与遗传育种重点实室油料脂质化学与营养湖北省重点实验室 
基金项目:国家自然科学基金(31571926);农业部中央级公益性科研院所基本科研业务费(1610172016005);中国农业科学院创新工程项目资助(CAAS-ASTIP-2013-OCRI);现代农业产业技术体系项目(CARS-13);湖北省技术创新专项(2018AHB014)
中文摘要:脂质在细胞和生物组织中发挥着重要作用,传统的脂质组学分析方法虽可以实现脂质鉴定,但脂质结构的多样性和相似性仍为脂质组学研究中全脂质分析提出了巨大的挑战。离子迁移谱是根据离子在缓冲气体或电力场中的迁移特性对其进行分离的技术,将离子迁移谱与传统脂质分析方法联用不仅有助于复杂脂质的分离,同时还可对脂质异构体进行分析鉴定,提高脂质分析的分辨率和选择性。该文主要对不同离子迁移质谱技术及其在脂质分析中的应用进行综述,并对其未来发展方向进行了展望。
中文关键词:脂质  离子迁移谱  离子迁移质谱技术  异构体
 
Ion Mobility Mass Spectrometry and Its Applications in Lipids Analysis
Abstract:Lipids play an essential role in cells and tissues as they are basic molecules responsible for the functions including structure supporting,energy storage and signal transduction.Although traditional analytical methods in lipidomics could provide a relative high selective and sensitive identification for lipids,the diversity and similarity in lipid structures still pose a great challenge toward the global analysis of lipids in biological samples.Ion mobility spectrometry(IMS) could separate the ions in buffer gas or electric field based on their mobility characteristics.The combination of IMS and traditional analysis approaches for lipids could not only attribute to the separation of sophisticated lipids,but also identify the lipid isomers,and thus improving the selectivity and resolution of lipid analysis.In this paper,various kinds of ion mobility mass spectrometry and their applications in lipids analysis were summarized,and their development prospects in future were expected as well.
Key Words:lipids  ion mobility spectrometry(IMS)  ion mobility mass spectrometry  isomer
引用本文:吴邦富,魏芳,谢亚,徐淑玲,吕昕,陈洪.离子迁移质谱技术及其在脂质分析中的应用[J].分析测试学报,2018,37(11):1388-1395.
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