| DNA发夹结构自组装信号放大策略应用的研究进展 |
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| 基金项目:江西省青年科学家(井冈之星)培养对象项目(2014BCB23004)；江西省食品药品监督管理局科技计划(2015SP13) |
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| 中文摘要:DNA发夹结构自组装因具有无酶参与、等温以及识别序列能力强等优点，在生物分子和金属离子检测方面展现了良好的发展前景。该文梳理了DNA发夹结构自组装信号放大策略的类型，综述了近年来该策略在致病菌、核酸肿瘤标记物、蛋白质、无机金属离子，以及生物小分子检测中应用的研究进展，并对其未来发展趋势进行了展望，旨在为基于DNA发夹结构自组装检测生物分子提供一定的参考。 |
| 中文关键词:DNA结构自组装 分析检测 研究进展 |
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| Research Progress in Application of Signal Amplification Strategy of Hairpin Structured DNA Self-assembly |
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| Abstract:Hairpin structured DNA self assembly is widely used in the detection on biomolecules as it possesses the advantages of enzyme free,isothermal and high recognition rate,etc.In this paper,the types of DNA self assembly and its application in the detection of foodborne pathogens,tumor marker,protein,inorganic metal and small biomolecules are briefly summarized,and its future developments are also discussed so as to provide a reference for the study of biomolecules based on hairpin structured DNA self assembly. |
| Key Words:DNA self assembly determination research progress |
| 引用本文：俞蓓，陈时建，徐天雄，占忠旭，赖卫华，许恒毅.DNA发夹结构自组装信号放大策略应用的研究进展[J].分析测试学报,2018,37(12):1514-1520. |
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