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多巴胺有序介孔硅表面分子印迹传感器的研制
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作者单位
龚伟,陈少珠,徐岚 1.西南大学化学化工学院2.重庆三峡医药高等专科学校 
基金项目:中央高校基本科研业务费专项资金(XDJK2009C091)
中文摘要:以多巴胺(DA)为模板,氨基修饰的介孔硅为载体,制得对多巴胺具有特异选择性的表面分子印迹聚合物(MIP)。将所得的MIP制成碳糊电极,用循环伏安法对多巴胺进行检测。在优化实验条件下,传感器的氧化峰电流与多巴胺浓度在1.0×10-7~2.0×10-6 mol/L和2.0×10-6~1.0×10-4 mol/L范围内呈良好的线性关系,相关系数分别为0.992 5 和0.996 9,检出限为1.3×10-9 mol/L。该传感器对DA具有较高的灵敏度和选择性,将其用于实际样品检测,结果满意。
中文关键词:表面分子印迹  介孔硅  电化学传感器  多巴胺
 
Preparation of Sensor for Dopamine Based on Surface Molecularly Imprinted Ordered Mesoporous Silica
Abstract:A molecularly imprinted polymer(MIP),which has a specific selectivity to dopamine,was synthesized using dopamine as template and 3-aminopropyltriethoxysilane modified mesoporous silica as carrier.The MIP was used to fabricate a sensor for the determination of dopamine,which response to dopamine(DA) was evaluated by cyclic voltammetry.Under the optimized conditions,the sensor displayed good linearities in the ranges of 1.0×10-7-2.0×10-6 mol/L and 2.0×10-6-1.0×10-4 mol/L with a lower detection limit of 1.3×10-9 mol/L.The correlation coefficients were 0.992 5 and 0.996 9,respectively.The studied imprinted sensor exhibited high sensitivity and selectivity,and was successfully applied in the determination of dopamine in human blood plasma.
Key Words:molecularly imprinted polymer  mesoporous silica  electrochemical sensor  dopamine
引用本文:龚伟,陈少珠,徐岚.多巴胺有序介孔硅表面分子印迹传感器的研制[J].分析测试学报,2012,31(4):417-422.
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