•  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
期刊检索


检索
检索项:
检索词:
总目录
  • WCSB9︱2019(第九届)世界采样和混样大会 查看全文>>
  • 关于召开第十五届全国青年分析测试学术报告会的通知 查看全文>>
友情链接
石墨烯量子点印迹传感器检测盐酸罗哌卡因
    点此下载全文
作者单位
张晓蕾,孙如宁,杨小弟* 1.中国药科大学高等职业技术学院2.南京师范大学化学与材料科学学院 
基金项目:中国药科大学中央高校基本科研业务费专项资金(JKQZ2013010)
中文摘要:采用热聚合法合成石墨烯量子点,再将石墨烯量子点通过π-π作用吸附在聚邻氨基苯酚膜表面,基于石墨烯量子点表面电化学印迹,制备石墨烯量子点-分子印迹传感器检测盐酸罗哌卡因。同时采用原子力显微镜表征石墨烯量子点尺寸,示差脉冲伏安法研究印迹响应机理。安培I~t曲线法发现传感器对盐酸罗哌卡因的响应线性范围为2.0×10-6~6.1×10-4 mol/L,检出限(S/N=3)为1.1×10-6 mol/L,与未使用石墨烯量子点的分子印迹传感器对比,石墨烯量子点-分子印迹传感器的线性范围变宽,检出限降低,空白加标回收率为91.0%~101%。将传感器用于血浆样品中盐酸罗哌卡因的检测,测得其浓度为4.21×10-6 mol/L,高效液相色谱法验证显示该方法的检测结果可靠,可用于临床样品的检测。
中文关键词:石墨烯量子点  分子印迹  盐酸罗哌卡因  邻氨基苯酚
 
Determination of Ropivacaine Hydrochloride with Graphene Quantum Dots-Molecularly Imprinted Polymer Electrochemical Sensor
Abstract:A novel electrochemical sensor for ropivacaine hydrochloride(RH) based on graphene quantum dots-molecularly imprinted polymer(MIP) modified glass carbon electrode was constructed.The graphene quantum dots(GQDs) were synthesized by the pyrolysis method,and adsorbed on the surface of conducting poly(o-aminophenol) membrane by π-π stacking,and then the o aminophenol as functional monomer and RH as template molecule were electrochemically imprinted on the film of GQDs to develop the GQDs-MIP sensor.The average lateral size of GQDs characterized by atomic force microscope(AFM) is about 20 nm.The response mechanism of the resulting sensor was investigated by differential pulse voltammetry and the linear relationship of sensor was determined by means of amperometric I-t curve.The results indicated that the calibration curve was linear in the range of 2.0×10-6-6.1×10-4 mol/L,and the detection limit(S/N=3)was 1.1×10-6 mol/L.Compared with the molecular imprinting sensor without GQDs,the GQDs-MIP sensor exhibited a wide linear range and a lower detection limit.The spiked recoveries were in the range of 91.0%-101%.The sensor was applied in the analysis of RH in plasma samples with RH concentration of 4.21×10-6 mol/L.In contrast to the detection result of high performance liquid chromatography(HPLC) method,this electrochemical analytical approach is credible,and could be applied in the detection of RH in clinical samples.
Key Words:graphene quantum dots(GQDs)  molecular imprinting  ropivacaine hydrochloride(RH)  o-aminophenol
引用本文:张晓蕾,孙如宁,杨小弟*.石墨烯量子点印迹传感器检测盐酸罗哌卡因[J].分析测试学报,2015,34(2):159-163.
摘要点击次数: 998
全文下载次数: 476
查看全文  查看/发表评论  下载PDF阅读器