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基于磁性分子印迹修饰电极的氯霉素电化学发光分析法
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作者单位
张若鹏,康天放,鲁理平,程水源 北京工业大学区域大气复合污染防治北京市重点实验室环境与能源工程学院 
基金项目:北京市教委科技计划重点项目(KZ201110005006);教育部博士点基金博导类项目(20131103110011)
中文摘要:基于氯霉素(CAP)强烈抑制Ru(bpy)2+3/三丙胺体系的电化学发光(ECL)信号,构建了一种高灵敏检测水体中CAP的磁性分子印迹电化学发光传感器。以Fe3O4-Au磁性纳米粒子为载体,对氨基苯硫酚(4-ATP)和2-丙烯酰胺-2-甲基丙基磺酸(AMPs)作为双功能单体,二甲基丙烯酸乙二酯(EGDMA)作为交联剂,过硫酸铵(APS)作为引发剂,通过自组装在Fe3O4-Au磁性纳米粒子表面合成氯霉素分子印迹膜(MIPs)。以修饰该磁性分子印迹聚合物的磁性玻碳电极(MGCE)为CAP电化学发光传感器。在优化实验条件下,ECL 信号变化值(ΔI=I0-Ip)随着CAP 浓度的增大而增大,且ΔI与CAP 浓度的对数在0.010~100 ng/L CAP浓度范围内呈良好线性关系,相关系数(r)为0.998 0,检出限为0.010 ng/L。研究结果表明,该传感器对CAP的检测灵敏度高,选择性好,线性范围宽,具有良好的应用前景。
中文关键词:电化学发光(ECL)  氯霉素(CAP)  分子印迹  联吡啶钌
 
Electrochemiluminescence Analysis of Chloramphenicol Based on Magnetic Molecularly Imprinted Modified Electrode
Abstract:A high sensitive electrochemiluminescence(ECL) sensor was established for the determination of chloramphenicol(CAP) in water based on magnetic molecularly imprinted technique and strong inhibitation of CAP on ECL signal of Ru(bpy)2+3/tripropyl amine system.Chloramphenicol molecularly imprinted membranes(MIPs) were synthesized on the surface of Fe3O4-Au magnetic nanoparticles by self assembly,using Fe3O4-Au magnetic nanoparticles as carriers,4 aminothiophenol(4-ATP)and 2-acrylamido-2-methylpropane sulfonic acid(AMPs) as binary functional monomers,ethylene dimethacrylate(EGDMA) as a cross linking agent and ammonium persulphate(APS) as an initiator.The magnetic glassy carbon electrode(MGCE) modified with the magnetic molecularly imprinted polymer was used as an ECL sensor for CAP.Under the optimal conditions,there was a good linear relationship for CAP with ECL quenching values of the system in the concentration range of 0.010-100 ng/L,with a correlation coefficient(r) of 0.998 0 and a detection limit of 0.010 ng/L.Results showed that the sensor has a good application prospect in the determination of CAP with advantages of high sensitivity,good selectivity and wide linear range.
Key Words:electrochemiluminescense(ECL)  chloramphenicol(CAP)  molecular imprinting  bipyridine ruthenium
引用本文:张若鹏,康天放,鲁理平,程水源.基于磁性分子印迹修饰电极的氯霉素电化学发光分析法[J].分析测试学报,2019,(2):169-175.
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