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“两面神”型金纳米粒子比色检测铁离子的新方法
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作者单位
陈心悦,哈伟,师彦平 1.中国科学院兰州化学物理研究所中国科学院西北特色植物资源化学重点实验室 甘肃省天然药物重点实验室2.中国科学院大学 
基金项目:国家自然科学基金项目(21405164,21575150,21775153);中科院青年创新促进会项目(2017457)
中文摘要:制备了一种聚乙二醇(PEG)和柠檬酸根不对称修饰的“两面神”型金纳米粒子(Janus AuNPs)比色传感器,并基于此建立了铁离子(Fe3+)比色检测的新方法。首先,利用柠檬酸钠还原法制备了粒径相对较大的金纳米粒子,随后,以玻片为基底,将大粒径金纳米粒子修饰在玻片上,利用玻片掩蔽部分柠檬酸根位点,并进一步在金纳米粒子非接触区域上修饰大量PEG链,得到柠檬酸根和PEG不对称修饰的Janus AuNPs。引入Fe3+后,有限区域内的柠檬酸根诱导Janus AuNPs发生定向聚集,形成金纳米粒子寡聚体并在水溶液中保持稳定。Janus AuNPs溶液吸光度比值与Fe3+浓度在1 μmol/L~10 mmol/L范围内呈线性变化(y=0.129x+0.317),检出限为715 nmol/L。与同类方法相比,该方法操作简便、灵敏度高,且可极大拓宽检测的线性范围。
中文关键词:“两面神”型金纳米粒子  不对称修饰  定向聚集  铁离子  比色传感
 
A Novel Colorimetric Detection Method for Iron Ion Based on Janus Gold Nanoparticles
Abstract:A novel colorimetric method for iron ion(Fe3+) detection was proposed by using asymmetrically modified Janus gold nanoparticles(Janus AuNPs) in this paper.Initially,citrate stabilized AuNPs with relatively large size were prepared through reduction reaction.Then,the large sized citrate stabilized AuNPs were immobilized on the glass slide,through which some binding sites on the surface of AuNPs were concealed.The stabilizing agent of polyethylene glycol(PEG) was further introduced onto the exposed surface of AuNPs to obtain the PEG and citrate asymmetrically modified Janus AuNPs.After the introduction of Fe3+,the aggregation behavior of Janus AuNPs was adjusted in an oriented and controllable manner to form oligomers which could remain stable in aqueous solution for a long time.Such an asymmetrical modification could significantly improve the dynamic detection range(1 μmol/L-10 mmol/L) of AuNPs based colorimetric assay.Meanwhile,a linear calibration curve,i.e.A750/A536=0.129c(μmol/L)+0.317 was also obtained,with a detection limit of 715 nmol/L.Compared with other nanoparticle based colorimetric system for Fe3+detection,this method is simple and sensitive,and surprisingly broadens the linear range for detection.
Key Words:Janus gold nanoparticles  asymmetrical modification  oriented aggregation  iron ion  colorimetric detection
引用本文:陈心悦,哈伟,师彦平.“两面神”型金纳米粒子比色检测铁离子的新方法[J].分析测试学报,2019,(5):574-580.
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