•  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
期刊检索


检索
检索项:
检索词:
总目录
  • WCSB9︱2019(第九届)世界采样和混样大会 查看全文>>
  • 关于召开第十五届全国青年分析测试学术报告会的通知 查看全文>>
友情链接
高效液相色谱-电感耦合等离子体质谱联用测定化妆品中六价铬与三价铬
    点此下载全文
作者单位
吴思霖,王欣美,潘晨,于建,张凯,王柯,郑荣 上海市食品药品检验所 
基金项目:上海市食品药品监督管理局资助项目(09DZ1975400)
中文摘要:建立了一种有效分离检测化妆品中Cr(Ⅵ)和Cr(Ⅲ)的高效液相色谱-电感耦合等离子体质谱(HPLC-ICP-MS)分析方法。以10 mmol/L(pH 7.0)EDTA为提取溶剂,0.075 mol/L 硝酸(pH 7.0,氨水调节)为流动相,采用Agilent Bio-WAX柱(4.6 mm×50 mm,5 μm)对样品提取液进行分离,电感耦合等离子体质谱进行测定。在优化实验条件下,Cr(Ⅵ)和Cr(Ⅲ)在0~100 μg/L 范围内线性关系良好,相关系数(r2)均为0.999 9。Cr(Ⅵ)和Cr(Ⅲ)的检出限分别为6、2 μg/kg,定量下限分别为18、6 μg/kg,加标回收率为85.1%~113%,相对标准偏差为0.4%~4.6%。实际样品的测定结果显示,在膏霜乳液类及粉类样品中检出Cr(Ⅵ)和Cr(Ⅲ)。该方法重现性好、灵敏度高,且Cr(Ⅵ)在中性条件下较稳定,不易转化为Cr(Ⅲ),适用于不同基质类型化妆品中Cr(Ⅵ)和Cr(Ⅲ)的同时检测。
中文关键词:高效液相色谱-电感耦合等离子体质谱(HPLC-ICP-MS)  化妆品  六价铬  三价铬
 
Determination of Chromium(Ⅵ) and Chromium(Ⅲ) in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry
Abstract:A method was developed for the simultaneous determination of chromium(Ⅵ) and chromium(Ⅲ) by high performance liquid chromatography-inductively coupled plasma mass spectrometry(HPLC-ICP-MS).The sample was extracted with 10 mmol/L EDTA solution(pH 7.0).The chromatographic separation was performed on an Agilent Bio-WAX column(4.6 mm×50 mm,5 μm) utilizing 0.075 mol/L nitric acid(pH 7.0) as mobile phase.Identification and quantitation were achieved by ICP-MS.Under the optimal conditions,the linear ranges for Cr(Ⅵ) and Cr(Ⅲ) were observed from 0 μg/L to 100 μg/L with correlation coefficients(r2) of 0.999 9.The limits of detection for Cr(Ⅵ) and Cr(Ⅲ) were 6 μg/kg and 2 μg/kg,and the limits of quantitation were 18 μg/kg and 6 μg/kg,respectively.Average recoveries for Cr(Ⅵ) and Cr(Ⅲ) at three spiked levels ranged from 85.1% to 113% with relative standard deviations of 0.4%-4.6%.Through the analysis of actual samples,Cr(Ⅵ) and Cr(Ⅲ) were detected out in cream lotion and powder cosmetics.With good reproducibility and high sensitivity,this method is suitable for the simultaneous determination of Cr(Ⅵ) and Cr(Ⅲ) in different types of cosmetics as Cr(Ⅵ) is stable under neutral conditions.
Key Words:high performance liquid chromatography-inductively coupled plasma mass spectrometry(HPLC-ICP-MS)  cosmetics  chromium(Ⅵ)  chromium(Ⅲ)
引用本文:吴思霖,王欣美,潘晨,于建,张凯,王柯,郑荣.高效液相色谱-电感耦合等离子体质谱联用测定化妆品中六价铬与三价铬[J].分析测试学报,2019,(6):724-727.
摘要点击次数: 77
全文下载次数: 99
查看全文  查看/发表评论  下载PDF阅读器