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高效液相色谱-电感耦合等离子体质谱法同时测定化妆品中5种含溴防腐剂
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潘晨,王枚博,吴思霖,王欣美,于建,张凯,王柯,郑荣 上海市食品药品检验所 
基金项目:中国食品药品检定研究院“化妆品中防腐剂的研究(2015-2017)”项目
中文摘要:建立了同时测定化妆品中苯扎溴铵、2 溴 2 硝基 1,3 丙二醇、5 溴 5 硝基 1,3 二烷、甲基二溴戊二腈、溴氯芬5种含溴防腐剂的高效液相色谱-电感耦合等离子体质谱法(HPLC-ICP-MS)。样品经含01%甲酸的甲醇溶液超声提取后,采用Agilent Eclipse-C18(150 mm×46 mm,5 μm)色谱柱分离,以01%甲酸-甲醇为流动相进行梯度洗脱,ICP-MS测定组分中的79Br,以保留时间定性,外标法定量。5种含溴防腐剂均在05~100 mg/L范围内线性关系良好(r>0999),检出限为15~30 μg/g,不同基质化妆品中的回收率为912%~108%,相对标准偏差(n=6)为13%~42%。该方法快速、准确、灵敏、专属性强,适用于化妆品中5种含溴防腐剂的定性定量分析。
中文关键词:高效液相色谱  电感耦合等离子体质谱  含溴防腐剂  化妆品
 
Determination of Five Bromine Contained Preservatives in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry
Abstract:A novel high performance liquid chromatography-inductively coupled plasma mass spectrometry(HPLC-ICP-MS) was established for the determination of five bromine contained preservatives,ie.benzalkonium bromide,2 bromo 2 nitro 1,3 propanediol,5 bromo 5 nitro 1,3 dioxane,methyldibromo glutaronitrile and bromochlorophene in cosmetics.The samples were ultrasonically pretreated with methanol containing 01%formic acid.The analytes containing 79Br were separated on an Agilent Eclipse-C18 column(150 mm×46 mm,5 μm) using 01%formic acid-methanol as mobile phases by gradient elution,and then analyzed by ICP-MS with external standard method.There were good linear relationships for five analytes in the range of 05-100 mg/L with correlation coefficients(r) larger than 0999.The detection limits for five bromine contained preservatives were in range of 15-30 μg/g.Recoveries for the analytes in different spiked cosmetics matrixes ranged from 912%to 108%with relative standard deviations(n=6) of 13%-42%.The method was fast,accurate,sensitive and selective,and was suitable for the simultaneous determination of five bromine contained preservatives in cosmetics.
Key Words:high performance liquid chromatography  inductively coupled plasma mass spectrometry  bromine contained preservatives  cosmetics
引用本文:潘晨,王枚博,吴思霖,王欣美,于建,张凯,王柯,郑荣.高效液相色谱-电感耦合等离子体质谱法同时测定化妆品中5种含溴防腐剂[J].分析测试学报,2019,38(7):830-834.
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