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γ-氨基丁酸键合硅胶毛细管色谱柱填料的绿色制备及其分析性能研究
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作者单位
赵双丽,罗菲菲,祝璐琪,王清江,何品刚 华东师范大学化学与分子工程学院 
基金项目:国家自然科学基金项目(21575042)
中文摘要:该文在水相溶剂中绿色合成了γ 氨基丁酸键合硅胶(Sil-GABA)色谱固定相,采用红外光谱、元素分析等对其进行了表征,并将制备的Sil-GABA材料作为毛细管色谱柱的填料研究了其色谱分离模式和分析性能。结果显示,在以乙酸铵水溶液为流动相的条件下,该填料可有效分离硝基氯苯3种位置异构体和7种磺胺,表明Sil-GABA固定相具有富水作用色谱的特性;在高浓度有机流动相条件下可有效分离4种苯甲酸类化合物,表明Sil-GABA具有亲水作用色谱的特性;此外,该Sil-GABA固定相在反相模式下对硝基苯胺异构体也有一定的分离能力。在优化条件下,7种磺胺保留时间的相对标准偏差小于32%,表明制得的色谱柱具有良好的重复性。该Sil-GABA固定相具有多种保留机理,在毛细管液相色谱分离领域具有潜在的应用价值。
中文关键词:γ-氨基丁酸键合硅胶  绿色合成  毛细管液相色谱
 
Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation
Abstract:A γ aminobutyric acid bonded silica(Sil-GABA) stationary phase was prepared in a green medium with only water as solvent,which was characterized by Fourier transform infrared spectroscopy and elemental analysis.The separation mode and analytical performance of the Sil-GABA stationary phase were evaluated through a series of experiments when it was used as packing material for capillary column.Results showed that three nitrochlorobenzene positional isomers and seven sulfonamides were separated effectively on the Sil-GABA stationary phase with ammonium acetate as mobile phase in an aqueous liquid chromatography mode.Four benzoic acid compounds were separated with high concentrations of organic solvents as mobile phases in a hydrophilic chromatography mode.Additionally,three nitroaniline positional isomers were also separated in a reversed phase chromatography mode.Under the optimal conditions,the relative standard deviations(RSD) of the retention times for the sulfonamides were within 32%,indicating that the Sil-GABA column has a good reproducibility.The prepared Sil-GABA stationary phase could provide potential applications in capillary liquid chromatography with multiple retention mechanisms.
Key Words:γ aminobutyric acid bonded silica(Sil-GABA)  green preparation  capillary liquid chromatography
引用本文:赵双丽,罗菲菲,祝璐琪,王清江,何品刚.γ-氨基丁酸键合硅胶毛细管色谱柱填料的绿色制备及其分析性能研究[J].分析测试学报,2019,38(7):865-869.
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