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现场制备表面增强拉曼光谱基底法快速检测药片中盐酸阿米洛利的含量
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作者单位
黄天雄,王文明,陈万超,陆偲倩,杜一平 上海功能性材料化学重点实验室,华东理工大学化学与分子工程学院 
基金项目:上海市科委科研计划项目(17142201100);上海烟草集团有限责任公司技术中心烟草行业卷烟烟气重点实验(K2013-1-044p)
中文摘要:利用加热贴(暖宝贴)作为热源现场合成银溶胶,并用其作为表面增强拉曼光谱(SERS)基底。使用罗丹明6G(R6G)作为探针分子,对合成的银溶胶的SERS性能进行评价。结果显示,银溶胶的制备方法简便、快速,制备时间在15 min内,具有较好的SERS增强效果,且在4 h内具有较好的稳定性。将现合成的银溶胶用于药片中盐酸阿米洛利的SERS检测,在0.8~8 mg/L范围内盐酸阿米洛利的质量浓度与拉曼峰强度有较好的线性相关系,线性方程为:y=1 395ρ-76.40,r2=0.999 2。检出限(LOD)为0.2 mg/L,其加标回收率为104%~106%,相对标准偏差为0.35%~3.5%。该方法简单快速、稳定性好,为药片中盐酸阿米洛利的快速检测和鉴别提供了新途径。
中文关键词:表面增强拉曼光谱(SERS)  盐酸阿米洛利  药片  银溶胶
 
Quantification of Amiloride Hydrochloride in Tablets by Surface Enhanced Raman Spectroscopy with in Situ Synthesized Substrate
Abstract:A surface enhanced Raman spectroscopy(SERS)with in situ synthesized silver colloid substrate was developed for the rapid detection of amiloride hydrochloride in tablets.The silver colloid substrate for surface enhanced Raman scattering was prepared using heating paster(warm baby)as heating source,and the SERS performance was evaluated with rhodamine 6G(R6G)as a SERS probe.Results indicated that the synthesis method for silver colloid was simple and rapid,and the substrate could be fabricated within 15 min and keep for 4 h with satisfactory stability and good SERS enhancement effect.It was applied in the SERS detection of amiloride hydrochloride in tablets.There was a linear relationship between SERS intensity and amiloride hydrochloride in the concentration range of 0.8-8 mg/L,with a curve equation of y=1 395ρ-76.40(r2 =0.999 2).The limit of detection was 0.2 mg/L,and the spiked recoveries from tablet samples were in the range of 104%-106% with relative standard deviations of 0.35%-3.5%.With the advantages of simpleness,rapidness and good stability,the developed method provides a new appraoch for the identification and rapid detection of amiloride hydrochloride in tablets.
Key Words:surface enhanced Raman spectroscopy(SERS)  amiloride hydrochloride  tablets  silver colloid
引用本文:黄天雄,王文明,陈万超,陆偲倩,杜一平.现场制备表面增强拉曼光谱基底法快速检测药片中盐酸阿米洛利的含量[J].分析测试学报,2019,(8):995-999.
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