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珠三角地区人群血浆中邻苯二甲酸酯的暴露水平研究
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陶斯湄,朱冬林,陈艳华,吴惠勤,周熙,徐长志,谢芝芝,陶玲,席云 1.中山大学附属第三医院药剂科2.中山大学附属第三医院检验科3.广州博康生物技术有限公司4.广东省测试分析研究所广东省化学危害应急检测技术重点实验室广东省分析测试技术公共实验室 
中文摘要:采用高效液相色谱-串联质谱(HPLC-MS/MS)法对珠三角地区人群血浆中16种邻苯二甲酸酯(PAEs)的暴露情况进行分析。样品预处理采用乙腈沉淀蛋白,正己烷液液萃取。结果表明,血浆中检出邻苯二甲酸二甲酯(DMP)、邻苯二甲酸二异丁酯(DiBP)、邻苯二甲酸二正丁酯(DnBP)、邻苯二甲酸丁基苄基酯(BBP)、邻苯二甲酸二环己基酯(DCHP)与邻苯二甲酸二(2-乙基己基)酯(DEHP)。其中DEHP的检出率为100%;其次为DiBP、DnBP与DMP,检出率分别为98.0%、62.0%和49.0%;DCHP与BBP的检出率最低,均为5.00%。∑PAEs的含量为12.4~1 399 ng/g,中值与平均值分别为39.8、57.7 ng/g。6种PAEs中DEHP占比最高,为90.01%~99.96%。对不同性别与年龄人群的PAEs暴露水平进行研究,发现女性与低年龄组(≤40 岁)人群血浆中的PAEs浓度较高,但仅DMP存在显著性差异。
中文关键词:邻苯二甲酸酯  珠三角地区  血浆  高效液相色谱-串联质谱
 
Investigation on Exposure Levels of Phthalates in Human Plasma Collected from the Pearl River Delta
Abstract:A high performance liquid chromatography-tandem mass spectrometric(HPLC-MS/MS) method was developed for the investigation on exposure levels of 16 phthalates(PAEs) in human plasma collected from the Pearl River Delta.Plasma samples were pretreated by protein precipitation with acetonitrile,and followed by liquid-liquid extraction with n hexane.Results demonstrated that 6 PAEs,i.e.dimethyl phthalate(DMP),diisobutyl phthalate(DiBP),di n butyl phthalate(DnBP),butyl benzyl phthalate(BBP),dicyclohexyl phthalate(DCHP) and di (2-ethyl hexyl) phthalate(DEHP) were detected in plasma samples.The detection rates for DEHP,DiBP,DnBP,DMP,DCHP and BBP were 100%,98.0%,62.0%,49.0%,5.00%and 5.00%,respectively.Contents for ∑PAEs were in the range of 12.4-1 399 ng/g,in which median and mean were 39.8 ng/g and 57.7 ng/g,respectively.DEHP occupied the highest ratio among the 6 PAEs,which was in the range of 90.01%-99.96%.By comparing the concentrations of PAEs in different sex and age groups,PAEs in female and less than 40 years old groups were detected with higher concentrations,and significant differences occured only in DMP concentrations of different sex and age groups.
Key Words:phthalates  Pearl River Delta  plasma  high performance liquid chromatography-tandem mass spectrometry
引用本文:陶斯湄,朱冬林,陈艳华,吴惠勤,周熙,徐长志,谢芝芝,陶玲,席云.珠三角地区人群血浆中邻苯二甲酸酯的暴露水平研究[J].分析测试学报,2019,38(11):1315-1320.
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