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基于Fe3O4磁性微粒分离富集的ICP-MS检测血清中铅的方法研究
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作者单位
杨茹,赵珍阳,龚子珊,汪曣,傅霜,韩文念,张勇,王世功,孙传强 1.天津大学精密仪器与光电子工程学院2.山东东仪光电仪器有限公司
3.天津国科医工科技发展有限公司
 
基金项目:国家863计划资助项目(2014AA020901);山东省重大科技创新工程项目(2018YFJH0302)
中文摘要:以FeCl3·6H2O为原料一步合成了粒径为400 nm的Fe3O4磁性微粒,并用于人血清中Pb2+的检测。用Zeta电位仪和单颗粒电感耦合等离子体质谱(SP-ICP-MS)对所合成的Fe3O4磁性微粒进行表征。通过微波消解法对血清样品进行预处理,经Fe3O4磁性微粒分离富集后,采用ICP-MS法检测。优化了Fe3O4磁性微粒分离富集Pb2+的实验条件,并在pH 5.0,吸附剂用量400 μL,吸附30 min的条件下,成功实现了血清中Pb2+的定量检测,富集因子为10。Pb2+的检出限为7 ng/L,定量下限为23.1 ng/L。
中文关键词:磁性微粒分离富集;电感耦合等离子体质谱(ICP-MS)  Pb2+;血清
 
Determination of Lead in Serum by ICP-MS Based on Magnetic Particle Enrichment
Abstract:Magnetic particles with a particle size of 400 nm were synthesized in one step by hydrothermal method for the detection of Pb2+ in human serum.They were characterized by Zeta potentiometry and single particle inductively coupled plasma mass spectrometry(SP-ICP-MS).The serum samples were pretreated by microwave digestion method,then separated and enriched with Fe3O4 magnetic particles,and finally detected by ICP-MS.Experimental conditions for the separation and enrichment of Pb2+ using Fe3O4 magnetic particles were optimized.The quantitative detection of Pb2+ in serum was successfully achieved at pH 50,using a 400 μL of adsorbent adsorbing for 30 min,and the enrichment factor was 10.The limit of detection(LOD) and the limit of quantitation(LOQ) were 7 ng/L and 23.1 ng/L,respectively.
Key Words:separation and enrichment of magnetic particles  inductively coupled plasma mass spectrometry(ICP-MS)  Pb2+  human serum
引用本文:杨茹,赵珍阳,龚子珊,汪曣,傅霜,韩文念,张勇,王世功,孙传强.基于Fe3O4磁性微粒分离富集的ICP-MS检测血清中铅的方法研究[J].分析测试学报,2019,38(11):1364-1368.
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