| 质谱技术在缺血性中风标志物发现中的应用及进展 |
| 点此下载全文 |
|
| 基金项目:国家自然科学基金项目(81874306) |
|
| 中文摘要:脑卒中是世界上主要的致死和致残的原因之一，缺血性脑卒中(IS)约占所有脑卒中案例的87%。由于IS存在黄金3 或 45 h的治疗窗，其早期筛查和快速诊断显得尤为重要。分子标志物的发现为IS的预测和诊断提供了新的思路。质谱技术可以快速灵敏地检测生物医学样本中的各种化合物，已被广泛应用于IS生物标志物的发现。该综述总结和讨论了质谱在IS标志物(特别是蛋白和小分子代谢物标志物)发现中的应用及其最新进展。 |
| 中文关键词:质谱 缺血性中风 生物标志物 蛋白 小分子代谢物 |
| |
| Recent Advances in Applications of Mass Spectrometry in Discovering Biomarkers for Ischemic Stroke |
|
|
| Abstract:Stroke is one of the leading causes for death and disability in the world,while ischemic stroke(IS) constitutes around 87 percent of stroke cases.Medical treatment should typically be made within 3 or 45 hours of stroke onset.Rapid diagnosis and early screening on IS are thus of great significance,and molecular biomarker is an effective strategy for this.Mass spectrometry is a choice of technique for detection of various compounds in biomedical samples,and has played important roles in discovery of biomarkers for IS.In this review,the recent advances in discovering biomarkers of IS,particularly those of the protein and metabolite biomarkers,are summarized and commented. |
| Key Words:mass spectrometry ischemic stroke biomarkers proteins metabolites |
| 引用本文：王健莹，吴茜，姚钟平.质谱技术在缺血性中风标志物发现中的应用及进展[J].分析测试学报,2020,39(1):44-49. |
| 摘要点击次数: 2487 |
| 全文下载次数: 1723 |
| 查看全文 下载PDF阅读器 |
|
|
