| 抗阿尔兹海默症藏药三味豆蔻汤的化学成分分析研究 |
| 点此下载全文 |
|
| 基金项目:国家重点研发计划项目(2017YFC1704000) |
|
| 中文摘要:三味豆蔻汤作为藏药的经典方剂，由药材豆蔻、香旱芹、荜茇和牦牛奶熬煮制成，其对阿尔兹海默症(Alzheimer′s disease，AD)具有一定的治疗作用。该方剂化学成分复杂且极性、挥发性差异大，相关的物质基础研究较少。该研究分别采用气相色谱-质谱(GC-MS)、超高效液相色谱-高分辨串联质谱(UPLC-HRMS/MS)技术针对三味豆蔻汤中不同极性组分进行检测分析，以了解其物质组成。结果显示：从三味豆蔻汤中共发现并鉴定出99个化学成分，分别为豆蔻和香旱芹中含有的含氧单萜和单萜烯类成分(如桉油精)、荜茇的生物碱类成分(如胡椒碱)以及牦牛奶含有的脂类成分(如甘油三酯等)。该结果可为了解三味豆蔻汤的药效物质基础提供重要依据。 |
| 中文关键词:三味豆蔻汤 阿尔兹海默症 气相色谱-质谱 超高效液相色谱-高分辨串联质谱 化学成分 |
| |
| Determination of Chemical Composition in Tibetan Drug Sanweidoukou Decoction Against Alzheimer′s Disease |
|
|
| Abstract:As a traditional prescription of Tibetan drug,Sanweidoukou decoction could be made from boiling herbal medicine cardamom,cumin,piper longum with yak milk together.It is reported to possess therapeutic efficacies against various diseases including Alzheimer′s disease(AD).However,its composition is still unclear due to its complex constituents with different polarities and volatilities.The principal objective of this research is to investigate the chemical constituents of the decoction.Considering different physicochemical properties of various components,gas chromatography tandem mass spectrometry(GC-MS) and ultra performance liquid chromatography coupled with high resolution mass spectrometry(UPLC-HRMS/MS) analysis were performed.As a result,99 compounds were identified and confirmed as monoterpenes or oxygenated monoterpenes from cardamom and cumin,such as eucalyptol,and alkaloids from piper longum such as piperine,as well as lipids from yak milk like triglycerides,etc.The results obtained provide a good support for further insight into Sanweidoukou decoctions pharmacological mechanism study in AD treatment. |
| Key Words:Sanweidoukou decoction Alzheimer′s disease gas chromatography mass spectrometry(GC-MS) ultra performance liquid chromatography coupled with high resolution tandem mass spectrometry(UPLC-HRMS/MS) chemical composition |
| 引用本文：尕曼，贺玖明，张瑞萍，李舒冉，刘庆山，更桑，多杰仁青，再帕尔·阿不力孜.抗阿尔兹海默症藏药三味豆蔻汤的化学成分分析研究[J].分析测试学报,2021,40(1):50-56. |
| 摘要点击次数: 1824 |
| 全文下载次数: 460 |
| 查看全文 下载PDF阅读器 |
|
|
