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样品预处理与实时直接分析质谱的联用技术及应用(英文)
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作者单位
刘敏,曹丹,李圣男,毕文韬 1.南京师范大学化学与材料科学学院江苏省生物医学材料重点实验室江苏省生物医学功能材料协同创新中心
2.广东科技贸易职业技术学院 
基金项目:the National Natural Science Foundation of China(21507062,21475061);the Natural Science of Foundation of Hebei Province(B2018201270);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry([2015]1098);Program of Natural Science Research of Jiangsu Higher Education Institutions of China(16KJB150022);the Priority Academic Program Development of Jiangsu Higher Education Institutions,Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
中文摘要:近年来,与实时直接分析质谱(DART-MS)相结合的样品预处理技术发展迅速,使得对复杂生物、环境、法医学、食品、个体小生物以及单细胞样品中的分析物进行直接分析成为可能。然而固体基质内部分析物检测困难、痕量分析物检测性能不佳已成为限制DART-MS进一步发展的关键问题。针对这些问题,多年来,研究人员在不同领域对样品预处理与质谱联用进行了多种尝试。该文以固相萃取(SPE)、分散固相萃取(DSPE)、搅拌棒吸附萃取(SBSE)、固相微萃取(SPME)、机械化学提取(MCE)和微波提取(MAE)等样品预处理技术为例,对不同研究领域中样品预处理技术与DART-MS联用的研究成果进行了综述,并对未来的发展趋势进行了展望。希望该综述能为开发与DART-MS联用的新型样品处理技术提供参考和帮助。
中文关键词:原位电离质谱;实时直接分析质谱(DART-MS);样品预处理  综述
 
Combination of Sample Pretreatment and Direct Analysis in Real-time Mass Spectrometry:Technologies and Applications
Abstract:In recent years,the rapid development of sample pretreatment techniques interfaced with direct analysis in real-time mass spectrometry(DART-MS) has allowed for the direct analysis on target analytes in complex biological,environmental,forensic and food environments,as well as individual small organisms and single cell samples.However,difficulties in detecting the internal analytes in solid matrices and the poor detection performance of trace analytes have become key problems restricting the further development of DART-MS.To solve these problems,several attempts have been made in different research fields to combine sample pretreatment methods with MS.The combinations of sample pretreatment techniques,such as solid-phase extraction(SPE),dispersive solid-phase extraction(DSPE),stir bar sorptive extraction(SBSE),solid-phase microextraction(SPME),mechanochemical extraction(MCE) and microwave-assisted extraction(MAE) with DART-MS are summarized in this review.The improvements that these combined methods may offer are detailed,and the future development trends are also proposed.It is hoped that this review will provide a reference or a basis for the future advancement of new sample treatment techniques in combination with DART-MS.
Key Words:ambient ionization mass spectrometry  direct analysis in real time mass spectrometry(DART-MS)  sample pretreatment technique  review
引用本文:刘敏,曹丹,李圣男,毕文韬.样品预处理与实时直接分析质谱的联用技术及应用(英文)[J].分析测试学报,2021,40(2):171-183.
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