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复杂样品的固相微萃取-直接质谱分析技术研究进展
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作者单位
郑亚君,路芳芳,张智平 西安石油大学化学化工学院 
基金项目:国家自然科学基金项目(21777128,21705125);陕西省自然科学基础研究计划项目(2019JC-33)
中文摘要:常压离子化质谱分析技术由于具有无需样品预处理、操作简单、分析效率高等特点,现已在复杂样品的快速分析方面发挥了重要作用。但是,该技术在质谱分析时将样品基质和待测化合物同时进行电离,样品基质对目标化合物的质谱分析造成了严重干扰。为了解决这一问题,在质谱直接分析前先采用固相微萃取技术对复杂样品中的目标化合物进行富集或基质去除,可极大地提高待测化合物的质谱分析灵敏度。该文着重综述了近几年发展起来可直接与常压电离源相联用或可原位电离目标化合物的固相微萃取技术,介绍了它们的原理及在复杂样品分析领域的应用,展望了固相微萃取-直接质谱分析技术的发展趋势。
中文关键词:复杂样品  固相微萃取  质谱  快速分析
 
Advances in Solid Phase Microextraction-Direct Mass Spectrometric Analysis for Complex Samples
Abstract:Ambient ionization mass spectrometry plays a pivotal role in the analysis of complex samples owing to the features of no sample pretreatment,easy to use and high efficiency.However,this methodology would result in a simultaneous ionization of sample matrices and target analytes,and the analysis sensitivity of mass spectrometry would be greatly reduced.Solid phase microextraction has been demonstrated to be an effective avenue either to enrich target analytes or to remove matrices from complex samples prior to mass spectrometric analysis,which significantly improves the limit-of-detection of determined compounds.In this work,recent advances in solid phase microextraction techniques,either being coupled directly to ambient ionization sources or capable of in situ ionization of target analytes,are reviewed,and their principles and applications to the analysis of complex samples are summarized.Moreover,the perspectives of solid phase microextraction direct mass spectrometric analysis have been exemplified based on the current development.
Key Words:complex sample  solid phase microextraction  mass spectrometry  rapid analysis
引用本文:郑亚君,路芳芳,张智平.复杂样品的固相微萃取-直接质谱分析技术研究进展[J].分析测试学报,2021,40(2):201-207.
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