| 超高效液相色谱-串联质谱法同时测定食品接触材料及制品中9种抗氧化剂迁移量 |
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| 基金项目:国家重点研发计划项目(2016YFF0203705)；广州海关科研项目(2020GZCK-026) |
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| 中文摘要:为了评估食品接触材料及制品中抗氧化剂的迁移风险，采用超高效液相色谱-串联质谱法(UPLC-MS/MS)建立了同时测定食品接触材料及制品中9种抗氧化剂迁移量的方法。采用C18色谱柱对迁移实验后的食品模拟物中9种抗氧化剂进行分离，1 mmol/L氟化铵和甲醇为流动相洗脱，采用电喷雾离子源(ESI)，多反应监测(MRM)正负离子模式进行扫描。结果表明，9种抗氧化剂的色谱分离效果良好，并在03~6 mg/L 质量浓度范围内与其峰面积均呈良好的线性关系，检出限为01 mg/L。加标回收率为 939%~106%，相对标准偏差(RSD)为080%~93%。该方法快速高效、线性范围好，适用于塑料食品接触材料及制品中9种抗氧化剂迁移量的检测。 |
| 中文关键词:食品接触材料及制品 抗氧化剂 超高效液相色谱-串联质谱法(UPLC-MS/MS) |
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| Simultaneous Determination of Specific Migration Amounts of 9 Antioxidants in Plastic Food Contact Materials by Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry |
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| Abstract:In order to assess the migration risk of antioxidants in food contact materials and products,an ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was established for the simultaneous determination of 9 antioxidants migration amounts in food contact materials and products.The separation of 9 antioxidants in the food simulant were performed on a C18 chromatographic column with 1 mmol/L ammonium fluoride-methanol as mobile phase.Under the electrospray ionization positive-negative mode,the antioxidants were detected in a multiple reaction monitoring mode,and quantified by the external standard method.Results indicated that this method exhibited a perfect performance in chromatographic separation.The calibration curves for the 9 antioxidants were linear in the range of 03-6 mg/L with their detection limits of 01 mg/L.The spiked recoveries ranged from 939% to 106% with relative standard deviations of 080%-93%.The method was suitable for the detection of migration amounts of 9 antioxidants in plastic food contact materials and products with the advantages of rapidness,high efficiency and good linear range. |
| Key Words:food contact materials and products antioxidants ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) |
| 引用本文：董犇,黎梓城,汪龙飞,鲍蕾,陈燕芬,钟怀宁,李丹,郑建国.超高效液相色谱-串联质谱法同时测定食品接触材料及制品中9种抗氧化剂迁移量[J].分析测试学报,2021,40(3):377-382. |
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