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超高效液相色谱-串联质谱法同时测定食品接触材料及制品中9种抗氧化剂迁移量
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作者单位
董犇,黎梓城,汪龙飞,鲍蕾,陈燕芬,钟怀宁,李丹,郑建国 1.广州海关技术中心广东广州5106232.雀巢(中国)食品安全研究院北京100015 
基金项目:国家重点研发计划项目(2016YFF0203705);广州海关科研项目(2020GZCK-026)
中文摘要:为了评估食品接触材料及制品中抗氧化剂的迁移风险,采用超高效液相色谱-串联质谱法(UPLC-MS/MS)建立了同时测定食品接触材料及制品中9种抗氧化剂迁移量的方法。采用C18色谱柱对迁移实验后的食品模拟物中9种抗氧化剂进行分离,1 mmol/L氟化铵和甲醇为流动相洗脱,采用电喷雾离子源(ESI),多反应监测(MRM)正负离子模式进行扫描。结果表明,9种抗氧化剂的色谱分离效果良好,并在03~6 mg/L 质量浓度范围内与其峰面积均呈良好的线性关系,检出限为01 mg/L。加标回收率为 939%~106%,相对标准偏差(RSD)为080%~93%。该方法快速高效、线性范围好,适用于塑料食品接触材料及制品中9种抗氧化剂迁移量的检测。
中文关键词:食品接触材料及制品  抗氧化剂  超高效液相色谱-串联质谱法(UPLC-MS/MS)
 
Simultaneous Determination of Specific Migration Amounts of 9 Antioxidants in Plastic Food Contact Materials by Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry
Abstract:In order to assess the migration risk of antioxidants in food contact materials and products,an ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was established for the simultaneous determination of 9 antioxidants migration amounts in food contact materials and products.The separation of 9 antioxidants in the food simulant were performed on a C18 chromatographic column with 1 mmol/L ammonium fluoride-methanol as mobile phase.Under the electrospray ionization positive-negative mode,the antioxidants were detected in a multiple reaction monitoring mode,and quantified by the external standard method.Results indicated that this method exhibited a perfect performance in chromatographic separation.The calibration curves for the 9 antioxidants were linear in the range of 03-6 mg/L with their detection limits of 01 mg/L.The spiked recoveries ranged from 939% to 106% with relative standard deviations of 080%-93%.The method was suitable for the detection of migration amounts of 9 antioxidants in plastic food contact materials and products with the advantages of rapidness,high efficiency and good linear range.
Key Words:food contact materials and products  antioxidants  ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)
引用本文:董犇,黎梓城,汪龙飞,鲍蕾,陈燕芬,钟怀宁,李丹,郑建国.超高效液相色谱-串联质谱法同时测定食品接触材料及制品中9种抗氧化剂迁移量[J].分析测试学报,2021,40(3):377-382.
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