| 鹅膏毒肽检测方法的研究进展 |
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| 基金项目:首都卫生发展科研专项(2018-4-1014);国家重点研发计划食品安全关键技术研发重点专项(2018YFC1602600);北京市城市管理能力提升专项重大项目(D171100008317001) |
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| 中文摘要:一直以来毒蘑菇中毒在全球范围内频发，成为最常见的食物中毒事件之一，也是食物中毒致死的最主要原因。毒蘑菇中含量最高、致死性最强的毒素为鹅膏毒肽。因此，鹅膏毒素准确快捷的检测对鉴别中毒源、患者后续治疗及预防有着重要意义。目前，鹅膏毒肽的常用检测方法包括色谱-质谱联用技术以及一些基于免疫识别和特殊化学结构的检测技术。而不断开发特异性强、灵敏度高、检测时间短的新型检测方法仍是目前的研究热点和重点。该文就鹅膏毒肽的检测方法进行综述，以期引起研究同行对此领域的关注，以激发更多的研究思路。 |
| 中文关键词:蘑菇中毒 鹅膏毒肽 质谱 快速检测 研究进展 |
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| Research Progress in Detection Methods for Amatoxin |
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| Abstract:Mushroom poisoning occurs frequently all over the world,which has become one of the most common food poisoning events,as well as the main cause of death from food poisoning.Meanwhile,the most and deadliest toxin in the poisonous mushroom is amatoxin.Hence,rapid and accurate detection of amanitin is of great significance for the identification of toxic source,and the subsequent treatment and prevention of patients.At present,the common methods for amanitin detection include chromatography-mass spectrometry and some other detection techniques based on immune recognition and special chemical structures.It is still the focus of current research that the development of new detection methods with strong specificity,high sensitivity and low time consumption.Therefore,the detection methods of amanitin are reviewed in this paper in order to arouse the attention of research colleagues in this field and stimulate more research ideas. |
| Key Words:mushroom poisoning amatoxin mass spectrometry rapid detection research progress |
| 引用本文：刘润卿,孙洁芳,牛宇敏,单文宠,邵兵.鹅膏毒肽检测方法的研究进展[J].分析测试学报,2021,40(4):503-509. |
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