| 磁性分子印迹电化学传感法检测痕量奥卡西平 |
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| 基金项目:国家自然科学基金资助项目（11475079） |
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| 中文摘要:该文以4-乙烯基吡啶和甲基丙烯酸酯为原料制备了一种可用于检测奥卡西平（OXC）的磁性分子印迹 电化学传感器（MNPs－MIP/MCPE）。首先，依据密度泛函数理论（DFT/B3LYP/6－31 + G）计算，实验成功地 筛选和构建出 OXC与功能单体的最佳组合及比例。随后，基于沉淀聚合法合成了能够识别 OXC的磁性分子 印迹膜（MNPs－MIP），将MNPs－MIP覆于碳糊电极（MCPE）表面制成MNPs－MIP/MCPE。采用差分脉冲伏安 法（DPV）将 MNPs－MIP/MCPE 传感器用于不同浓度 OXC 的测定。结果显示，传感器的峰电流信号随 OXC 浓 度的增大而增大，且OXC分别在5 × 10－8 ～3 × 10－6 mol/L和3 × 10－6 ～1. 5 × 10－4 mol/L浓度范围内与其峰电流 信号呈线性关系，其线性方程分别为：Ip （μA）= 1. 755 + 1. 097c（μmol/L），相关系数（r）= 0. 999 7 和 Ip （μA）= 0. 131 + 5. 177c（μmol/L），r = 0. 999 6。OXC的检出限（LOD = 3S/m）为2. 06 × 10－8 mol/L。该传感器成 功用于实际样品中OXC含量的检测，其回收率为99. 4%~101%，相对标准偏差（RSD）为1. 5%～2. 5%。 |
| 中文关键词:分子印迹 电化学传感器 磁性碳糊电极 检测 奥卡西平 |
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| Detection of Oxcarbazepine Using an Electrochemical Sensor Based on Magnetic Molecularly Imprinted Membrane |
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| Abstract:In this paper，a magnetic molecularly imprinted electrochemical sensor（MNPs－MIP/ MCPE）for the detection of oxcarbazepine（OXC）was prepared，using 4-vinylpyridine and methacry? late as raw materials. Firstly，according to the calculation of the density functional theory（DFT/ B3LYP/6－31 + G），the best combination and the best combination ratio of the OXC with functional monomers were successfully screened and constructed. Subsequently，a magnetic molecularly im? printed membrane（MNPs－MIP）capable of recognizing OXC was synthesized based on the precipita? tion polymerization method，which was coated on the surface of a carbon paste electrode（MCPE）to make a magnetic molecularly imprinted sensor of MNPs－MIP/MCPE. The sensor was used for the de? termination of different concentrations of OXC solutions with differential pulse voltammetry（DPV）. Results showed that，the current signals of the system had good linear relationship（r > 0. 999）with OXC concentrations in the ranges of 5 × 10－8 －3 × 10－6 mol/L and 3 × 10－6 －1. 5 × 10－4 mol/L，and their linear equations were Ip （μA）= 1. 755 + 1. 097c（μmol/L）and Ip （μA）= 0. 131 + 5. 177c （μmol/L），respectively. The detection limit for OXC（LOD = 3S/m）was 2. 06 × 10－8 mol/L. The sen? sor was used for the detection of OXC concentration in the actual samples，with recoveries of 99. 4%－ 101% and relative standard deviations（RSD）of 1. 5%－2. 5%. |
| Key Words:molecularly imprinted membrane ?electrochemical sensor ?magnetic carbon paste electrode ?detection ?oxcarbazepine |
| 引用本文：张 迪，李强翔，王志梅，廖力夫，肖锡林.磁性分子印迹电化学传感法检测痕量奥卡西平[J].分析测试学报,2021,40(8):1136-1144. |
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