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溶胶-凝胶分子印迹CsPbBr3量子点的构建及其在胆固醇荧光检测中的应用
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作者单位
宋敏霞,管 杰,陈 璐,舒 韵,徐 琴,胡效亚 扬州大学 化学化工学院江苏 扬州 225002 
基金项目:国家自然科学基金资助项目(NSFC 22076161,21675140,21705141)
中文摘要:该文研究了CsPbBr3量子点(QDs)作为一种新型荧光(FL)探针对胆固醇(CHO)的检测。以3-氨丙基三乙氧基硅烷(APTES)为功能单体,CHO为模板分子,采用溶胶-凝胶技术,将CHO引入到SiO2网络中,制备了CHO分子印迹膜保护的CsPbBr3@SiO2 QDs。该分子印迹膜既可降低空气、湿度等与CsPbBr3 QDs的接触,提高CsPbBr3 QDs的稳定性,又赋予CsPbBr3 QDs对CHO的选择性。检测过程中,CHO被捕获到CsPbBr3@SiO2QDs的印迹位点上,形成空间位阻,导致CsPbBr3 QDs荧光强度下降。在最优条件下,CsPbBr3 QDs的荧光猝灭效率和CHO浓度对数在1.00 × 10-11 ~ 5.00 × 10-8 mol·L-1范围内呈现良好的线性关系,检出限为2.48 × 10-12 mol·L-1。结果表明,该方法灵敏度高、选择性好。该工作为CHO检测提供了一种新的策略,拓宽了CsPbBr3 QDs的应用范围。
中文关键词:溶胶-凝胶  钙钛矿量子点  胆固醇  荧光传感器
 
Construction of a Sol-Gel Molecularly Imprinted CsPbBr3 Quantum Dots Probe and Its Application in Fluorescence Detection of Cholesterol
Abstract:In this work, CsPbBr3 quantum dots(QDs) were used as a new kind of fluorescence(FL)probe to detect cholesterol(CHO). By using 3-aminopropyltrimethoxysilane(APTES) as the functional monomer and CHO as the template molecule, a CHO molecularly imprinted layer was formed on CsPbBr3 QDs via a simple silica sol-gel process. The formed silica layer not only improve the stability of CsPbBr3 QDs by protecting CsPbBr3 QDs from direct exposure to air and humidity, but also renders CsPbBr3 QDs good selectivity to CHO. During the detection process, CHO was captured into the specific cavity sites of CHO-imprinted SiO2 shell layers on CsPbBr3@SiO2 QDs to cause the decrease of the FL intensity of CsPbBr3 QDs. Under the optimal conditions, a good linear relationship was obtained between fluorescence quenching efficiency and the logarithm of CHO concentrations in the range of 1.00 × 10-11-5.00 × 10-8 mol·L-1, with a detection limit down to 2.48 × 10-12 mol·L-1. This sensor showed better sensitivity and selectivity to CHO than to other interferences. This work broadens the application horizon of CsPbBr3 QDs and provides a new strategy for CHO detection.
Key Words:sol-gel  perovskite quantum dots  cholesterol  fluorescence sensor
引用本文:宋敏霞,管 杰,陈 璐,舒 韵,徐 琴,胡效亚.溶胶-凝胶分子印迹CsPbBr3量子点的构建及其在胆固醇荧光检测中的应用[J].分析测试学报,2021,40(9):1367-1373.
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