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基于UHPLC-QTOF MS的PLA吸管中未知物的筛查识别
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作者单位
吴景杰,叶蕾,支朝晖,夏伊宁 1. 中国农业科学院 农业质量标准与检测技术研究所北京 100081 2. 常州龙骏天纯环保科技有限公司 江苏 常州 213100 
基金项目:国家重点研发计划课题(2018YFC1603204);国家自然科学基金国际(地区)合作与交流项目(32061160474)
中文摘要:该文采集了不同的PLA吸管样品,通过迁移实验模拟PLA吸管的不同使用场景,再采用超高效液相色谱-飞行时间质谱(UHPLC-QTOF MS)技术分析PLA吸管向食品模拟液中迁移的化学物质,通过靶向筛查与非靶向筛查相结合的方式共识别出30个迁移物,不同吸管样品之间以及不同食品模拟液之间的迁移物有所差异。识别的迁移物可分为低聚物和添加剂两类,其中低聚物可视为非有意添加物,主要为聚丁二酸丁二醇酯(PBS)和丁二醇-己二酸-对苯二甲酸共聚物(PBAT),以环状结构为主;添加剂包括抗氧剂、润滑剂和增塑剂,以及与之相关的非有意添加物(原料、杂质、副反应产物等)。所有迁移物中,仅5种在GB9685-2016的肯定列表中,其余物质采用毒理学关注阈值(TTC)方法结合Cramer决策树进行危害评估,大部分被判定为Cramer Ⅲ类(高毒)物质,需予以更多关注以确保PLA吸管使用安全。
中文关键词:PLA吸管  超高效液相色谱-飞行时间质谱  迁移物筛查  危害评估
 
Identification of Migrants from Polylactic Acid Straws by Ultrahigh Performance Liquid Chromatography-Quadrupole Time-of-flight Mass Spectrometry
Abstract:In this study,different polylactic acid(PLA) straw samples were collected,and migration experiments were carried out to simulate the usage of PLA straws in real cases. Then,an ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS) method was developed for analysis of the chemicals migrated from PLA straws into food simulants.Identification of the migrants was performed via both targeted and non-targeted screening procedures.A total of 30 migrants were identified in different straw samples and food simulants. These identified migrants could be divided into two categories,i.e. oligomers and additives.Considered as non-intentionally added substances(NIAS),the oligomers mainly included polybutylene succinate(PBA) and butylene glycol-hexane diacid-terephthalate acid copolymer(PBAT) in cyclic form.The additives included antioxidants,lubricants and plasticizers, as well as the NIAS related to them such as raw materials,impurities,byproducts,etc.Among all migrants,only 5 of them were found in the positive list of GB9685-2016.Hazard assessment on the rest migrants were performed using threshold of toxicological concern(TTC) approach combined with Cramer decision tree.Most of them were assigned Cramer class Ⅲ(high toxicity),which required special attention to ensure the safe use of PLA straws.
Key Words:PLA straws  ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS)  migrant identification  hazard assessment
引用本文:吴景杰,叶蕾,支朝晖,夏伊宁.基于UHPLC-QTOF MS的PLA吸管中未知物的筛查识别[J].分析测试学报,2021,40(11):1627-1632.
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