| 半花菁染料用于分子影像的研究进展 |
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| 基金项目:the National Natural Science Foundation of China（21904002）；the Natural Science Foundation of Anhui Province（2008085QB94） |
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| 中文摘要:分子影像广泛用于基本的生物学过程研究，众多疾病诊断、治疗策略设计以及疗效评估。半花菁染料具有良好的光物理性质、生物相容性和对生物系统的低毒性，是一种比较理想的生物成像试剂。近年来，出现了大量基于半花菁染料的探针用于分子成像的研究工作。该文系统地介绍了基于半花菁染料的探针用于荧光和多模态成像的研究进展，详细地介绍了这些可激活的半花菁探针的设计策略以及作为生物成像试剂的成功应用。最后，讨论了半花菁探针用于分子成像的发展前景。 |
| 中文关键词:半花菁染料 ?分子影像 ?荧光成像 ?多模态成像 |
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| Research Progress of Hemicyanine Dye for Molecular Imaging |
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| Abstract:Molecular imaging has been widely applied to the research of fundamental biological processes，diagnosis，treatment design and therapeutic outcome assessment on many diseases．Hemicyanine（HCy） dye is a suitable bioimaging agent due to its good photophysical properties，biocompatibility and low toxicity to living systems．A huge amount of research work involving probes based on the HCy dye for molecular imaging has emerged in recent years．This review focuses on the development of probes based on HCy dye for fluorescence and multimodal imaging in a systematic manner．Design strategies of the activatable HCy probes and their successful applications as bioimaging agents are described in detail. In addition，the future development of HCy probes for molecular imaging is discussed． |
| Key Words:hemicyanine ?molecular imaging ?fluorescence imaging ?multimodal imaging |
| 引用本文：吴方铮，张乐乐，海子娟，.半花菁染料用于分子影像的研究进展[J].分析测试学报,2022,41(4):454-466. |
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