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DNA原位自组装用于细胞荧光成像分析研究
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作者单位
王思成,韩挺,王广凤 1. 安徽师范大学 化学与材料科学学院化学生物传感重点实验室和功能分子固体安徽省重点实验室安徽 芜湖 2410002. 北德克萨斯大学 化学系Denton 76201 
基金项目:The Key Project of National Natural Science Foundation of China(21936001);The National Natural Science Foundation
中文摘要:DNA自组装由于其低毒性、高生物相容性和内置特性,在生物传感、药物递送和临床治疗中发挥着越来越重要的作用。与大多数天然聚合物或合成纤维相比,这些DNA分子相对坚固,可通过序列变异进行修饰。作为侧链连接到聚合物上形成的二级结构赋予DNA结构可设计的响应特性,如对金属离子、蛋白质、pH、DNA、RNA和其他一些小信号分子(如ATP)的响应,可实现DNA原位自组装并进一步用于细胞荧光成像分析。该文综述了DNA自组装的最新进展,重点介绍了引发剂,并以触发机制分类探究其荧光成像应用。
中文关键词:DNA原位自组装  ?荧光成像  ?活细胞  ?触发机制
 
Progress on In-situ DNA Self-assemblies for Cellular Fluorescence Imaging Analysis
Abstract:DNA self-assemblies play an increasingly significant role in biosensing,drug delivery and therapy due to their minimal toxicity,high biocompatibility and built-in features.Compared to most natural polymers or synthetic fibers,these DNA molecules could be relatively strong while also modifiable through sequence variation.By simply attaching to a polymer as a side chain,the secondary structure formed could endow the DNA structure with designable responsiveness to something like metal ions,proteins,pH,DNA,RNA,and some other small signal molecules(such as ATP) response to achieve some functional self-assemblies.In this review,the most recent progress of DNA self-assembly is introduced.The focus is on the initiator to distinguish the trigger mechanism and their fluorescence imaging applications.
Key Words:in-situ DNA self-assembly  ?fluorescence imaging  ?living cell  ?trigger mechanism
引用本文:王思成,韩挺,王广凤.DNA原位自组装用于细胞荧光成像分析研究[J].分析测试学报,2022,41(4):570-577.
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