| 超小尺寸聚焦硫量子点荧光传感探针的制备及传感应用 |
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| 基金项目:The National Natural Science Foundation of China（21675024，21874020）；The Program for Innovative Leading Talents in Fujian Province（2016B016）；The Program for Fujian Youth Talent Support Project（2019B016） |
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| 中文摘要:采用简单的组装－裂变法和透析后处理技术相结合的方法，制备了一种超小尺寸聚焦的荧光硫量子点（SQDs）。采用透射电子显微镜（TEM）、X射线能谱（EDX）、紫外－可见吸收光谱（UV－Vis）和荧光光谱对所制备的SQDs进行了表征。结果表明，平均粒径为2.2 nm的SQDs在水溶液中具有非激发波长依赖特性和光学稳定性。并且Fe3+会显著猝灭SQDs的荧光，推测其猝灭机制为内滤效应（IFE）。基于Fe3+对该SQDs产生的荧光猝灭效应，成功构建了一种简便、高选择性和高灵敏度的检测Fe3+的荧光分析平台。该方法检测Fe3+的线性范围为5～600 μmol/L，检出限（LOD）为1.19 μmol/L，并成功实现了血清样本中Fe3+的检测。该方法操作简单、成本低，且具有高灵敏度、高选择性等优点，为SQDs及其相关探针制备提供了一种简单有效的方法，在临床诊断中具有较好的应用前景。 |
| 中文关键词:硫量子点 ?组装－裂变法 ?透析后处理技术 ?三价铁离子 |
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| Simple Synthesis of Ultra-small Size Focused Sulfur Quantum Dots for Fluorescence Sensing |
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| Abstract:A facile assembly－fission method combined with dialysis post-treatment strategy was adopted to prepare a kind of ultra-small size focused fluorescent sulfur quantum dots（SQDs）．The as-prepared SQDs were characterized by transmission electron microscopy（TEM），energy-dispersive X-ray spectroscopy（EDX），UV－Vis absorption spectrometry（UV－Vis） and fluorescence spectrometry．The photoluminescence properties of the SQDs were investigated in detail，which indicated that the SQDs with the average diameter of 2.2 nm exhibited an excitation-independent emission and an optical stability in aqueous solution．Meanwhile，the fluorescence of the SQDs could be quenched by Fe3+ significantly，and the mechanism for the fluorescence quenching was via inner filter effect（IFE）．Based on the fluorescence quenching effect of the Fe3+/SQDs system，a facile fluorescence sensing platform was successfully constructed for the highly selective and sensitive detection of Fe3+．The proposed SQD-based sensor showed a wide response to Fe3+ in the range of 5－600 μmol/L，with a detection limit（LOD） of 1.19 μmol/L．In addition，this method，with significant advantages of high sensitivity，high selectivity，simplicity and economy，was successfully applied to the detection of Fe3+ in human serum，avoiding the deficiencies of complex sample preparation and expensive detection conditions．Thus，this method has a potential application prospect in clinical diagnosis，and opens up a new way for the design of effective fluorescent probes for other biologically related targets． |
| Key Words:sulfur quantum dots ?assembly－fission ?dialysis post-treatment ?ferric iron |
| 引用本文：郑琼华，盛依伦，张善彪，黄种南，陈伟，彭花萍.超小尺寸聚焦硫量子点荧光传感探针的制备及传感应用[J].分析测试学报,2022,41(4):618-624. |
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