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超小尺寸聚焦硫量子点荧光传感探针的制备及传感应用
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作者单位
郑琼华,盛依伦,张善彪,黄种南,陈伟,彭花萍 福建医科大学 药物分析学系福建省高等学校纳米医药技术重点实验室福建 福州 350004 
基金项目:The National Natural Science Foundation of China(21675024,21874020);The Program for Innovative Leading Talents in Fujian Province(2016B016);The Program for Fujian Youth Talent Support Project(2019B016)
中文摘要:采用简单的组装-裂变法和透析后处理技术相结合的方法,制备了一种超小尺寸聚焦的荧光硫量子点(SQDs)。采用透射电子显微镜(TEM)、X射线能谱(EDX)、紫外-可见吸收光谱(UV-Vis)和荧光光谱对所制备的SQDs进行了表征。结果表明,平均粒径为2.2 nm的SQDs在水溶液中具有非激发波长依赖特性和光学稳定性。并且Fe3+会显著猝灭SQDs的荧光,推测其猝灭机制为内滤效应(IFE)。基于Fe3+对该SQDs产生的荧光猝灭效应,成功构建了一种简便、高选择性和高灵敏度的检测Fe3+的荧光分析平台。该方法检测Fe3+的线性范围为5~600 μmol/L,检出限(LOD)为1.19 μmol/L,并成功实现了血清样本中Fe3+的检测。该方法操作简单、成本低,且具有高灵敏度、高选择性等优点,为SQDs及其相关探针制备提供了一种简单有效的方法,在临床诊断中具有较好的应用前景。
中文关键词:硫量子点  ?组装-裂变法  ?透析后处理技术  ?三价铁离子
 
Simple Synthesis of Ultra-small Size Focused Sulfur Quantum Dots for Fluorescence Sensing
Abstract:A facile assembly-fission method combined with dialysis post-treatment strategy was adopted to prepare a kind of ultra-small size focused fluorescent sulfur quantum dots(SQDs).The as-prepared SQDs were characterized by transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy(EDX),UV-Vis absorption spectrometry(UV-Vis) and fluorescence spectrometry.The photoluminescence properties of the SQDs were investigated in detail,which indicated that the SQDs with the average diameter of 2.2 nm exhibited an excitation-independent emission and an optical stability in aqueous solution.Meanwhile,the fluorescence of the SQDs could be quenched by Fe3+ significantly,and the mechanism for the fluorescence quenching was via inner filter effect(IFE).Based on the fluorescence quenching effect of the Fe3+/SQDs system,a facile fluorescence sensing platform was successfully constructed for the highly selective and sensitive detection of Fe3+.The proposed SQD-based sensor showed a wide response to Fe3+ in the range of 5-600 μmol/L,with a detection limit(LOD) of 1.19 μmol/L.In addition,this method,with significant advantages of high sensitivity,high selectivity,simplicity and economy,was successfully applied to the detection of Fe3+ in human serum,avoiding the deficiencies of complex sample preparation and expensive detection conditions.Thus,this method has a potential application prospect in clinical diagnosis,and opens up a new way for the design of effective fluorescent probes for other biologically related targets.
Key Words:sulfur quantum dots  ?assembly-fission  ?dialysis post-treatment  ?ferric iron
引用本文:郑琼华,盛依伦,张善彪,黄种南,陈伟,彭花萍.超小尺寸聚焦硫量子点荧光传感探针的制备及传感应用[J].分析测试学报,2022,41(4):618-624.
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