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吲唑酰胺类合成大麻素的EI质谱特征分析
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作者单位
徐仿敏,李海波,魏万里,王瑞花,刘凌云,李强 1. 江苏省江阴市公安局物证鉴定室江苏 江阴 214431 2. 江苏省常州市公安局物证鉴定所江苏 常州 213003 3. 江苏省无锡市公安局物证鉴定所江苏 无锡 214001 4. 公安部物证鉴定中心北京 110038 
基金项目:中央公益性科研院所基本科研业务费专项资金项目(2021JB007)
中文摘要:采用气相色谱-质谱联用技术(GC-MS)对 9 种吲唑酰胺类合成大麻素(MDMB-CHMINACA、5F-AB-PINACA、5F-AMB、AB-CHMINACA、AB-FUBINACA、AB-PINACA、MDMB-FUBINACA、AMB-FUBINACA、ADB-BUTINACA)在电子轰击(EI)电离模式下产生的主要碎片离子和碎裂过程进行分析,并对所获得的质谱图进行解析,推测该类物质的EI碎裂规律。结果表明,在EI模式下,吲唑酰胺类合成大麻素的吲唑3号位酰胺基C—N键的断裂是主要碎裂方式,在碎裂过程中还存在麦氏重排。该研究总结了吲唑酰胺类合成大麻素在EI模式下的主要碎片离子和质谱特征,归纳了EI的特征碎裂规律,可为吲唑酰胺类合成大麻素的结构推断与鉴定提供参考。
中文关键词:新精神活性物质  合成大麻素  吲唑酰胺类  气相色谱  质谱特征
 
Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids
Abstract:A gas chromatography-mass spectrometry(GC-MS) was applied to investigate the mass fragmentation characteristics of 9 indazole-3-carboxamide analogues synthetic cannabinoids in electron ionization(EI),including MDMB-CHMINACA,5F-AB-PINACA,5F-AMB,AB-CHMINACA,AB-FUBINACA,AB-PINACA,MDMB-FUBINACA,AMB-FUBINACA and ADB-BUTINACA.The obtained mass spectra were analyzed and the EI fragmentation patterns of indazole-3-carboxamide analogues synthetic cannabinoids were speculated.Results showed that in the EI mode,the C—N cleavage of the amide group connected to the indazole ring at position 3 is the main fragmentation pathway,and the McLafferty rearrangement was happened during the fragmentation.The main fragmentation ions and mass fragmentation characteristic of indazole-3-carboxamide analogues synthetic cannabinoids in EI modes were summarized in this paper,which is useful for identification on the new psychoactive substances of unknown indazole-3-carboxamide analogues synthetic cannabinoids in practical work.
Key Words:new psychoactive substances  synthetic cannabinoids  indazole-3-carboxamide  gas chromatography  mass fragmentation characteristics
引用本文:徐仿敏,李海波,魏万里,王瑞花,刘凌云,李强.吲唑酰胺类合成大麻素的EI质谱特征分析[J].分析测试学报,2022,41(7):1030-1035.
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