| 吲唑酰胺类合成大麻素的EI质谱特征分析 |
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| 基金项目:中央公益性科研院所基本科研业务费专项资金项目（2021JB007） |
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| 中文摘要:采用气相色谱－质谱联用技术（GC－MS）对 9 种吲唑酰胺类合成大麻素（MDMB－CHMINACA、5F－AB－PINACA、5F－AMB、AB－CHMINACA、AB－FUBINACA、AB－PINACA、MDMB－FUBINACA、AMB－FUBINACA、ADB－BUTINACA）在电子轰击（EI）电离模式下产生的主要碎片离子和碎裂过程进行分析，并对所获得的质谱图进行解析，推测该类物质的EI碎裂规律。结果表明，在EI模式下，吲唑酰胺类合成大麻素的吲唑3号位酰胺基C—N键的断裂是主要碎裂方式，在碎裂过程中还存在麦氏重排。该研究总结了吲唑酰胺类合成大麻素在EI模式下的主要碎片离子和质谱特征，归纳了EI的特征碎裂规律，可为吲唑酰胺类合成大麻素的结构推断与鉴定提供参考。 |
| 中文关键词:新精神活性物质 合成大麻素 吲唑酰胺类 气相色谱 质谱特征 |
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| Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids |
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| Abstract:A gas chromatography－mass spectrometry（GC－MS） was applied to investigate the mass fragmentation characteristics of 9 indazole-3-carboxamide analogues synthetic cannabinoids in electron ionization（EI），including MDMB－CHMINACA，5F－AB－PINACA，5F－AMB，AB－CHMINACA，AB－FUBINACA，AB－PINACA，MDMB－FUBINACA，AMB－FUBINACA and ADB－BUTINACA．The obtained mass spectra were analyzed and the EI fragmentation patterns of indazole-3-carboxamide analogues synthetic cannabinoids were speculated．Results showed that in the EI mode，the C—N cleavage of the amide group connected to the indazole ring at position 3 is the main fragmentation pathway，and the McLafferty rearrangement was happened during the fragmentation．The main fragmentation ions and mass fragmentation characteristic of indazole-3-carboxamide analogues synthetic cannabinoids in EI modes were summarized in this paper，which is useful for identification on the new psychoactive substances of unknown indazole-3-carboxamide analogues synthetic cannabinoids in practical work． |
| Key Words:new psychoactive substances synthetic cannabinoids indazole-3-carboxamide gas chromatography mass fragmentation characteristics |
| 引用本文：徐仿敏，李海波，魏万里，王瑞花，刘凌云，李强.吲唑酰胺类合成大麻素的EI质谱特征分析[J].分析测试学报,2022,41(7):1030-1035. |
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