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检测SARS-CoV-2的电化学生物传感器研究进展
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作者单位
窦雪晨,王冠,张宁,程智,杜耀华,田丰 军事科学院系统工程研究院 卫勤保障技术研究所天津 300161 
基金项目:军队重点项目(20SWAQX06
中文摘要:电化学传感器因具有灵敏、便携、稳健性高、小型化、成本低、无需前处理、检测快速等优点,在严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)检测领域受到广泛关注。该文介绍了致病菌SARS-CoV-2的组成部分,综述了基于病毒表面的刺突蛋白、病毒内部核衣壳蛋白和核糖核酸(RNA) 3种可特异性检测SARS-CoV-2的电化学生物传感器的研究进展,并对比了3种类型电化学生物传感器的检出限、检测时间、动态监测范围等关键参数。同时与其他检测SARS-CoV-2的方法进行对比,分析了电化学生物传感器的优劣势;最后指出了未来可通过优化检测电极材料及反应条件、修饰检测探针等方面提升电化学生物传感器性能,以实现对新型冠状病毒肺炎(COVID-19)患者的早发现、早隔离及早治疗,同时为设计现场快速诊断COVID-19设备提供有力支撑。
中文关键词:严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)  电化学生物传感器  刺突蛋白  核衣壳蛋白  核糖核酸(RNA)  COVID-19
 
Research Progress on Electrochemical Biosensors for SARS-CoV-2 Detection
Abstract:Electrochemical sensors have attracted widespread attention in the field of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) detection owing to their characteristics of high sensitivity,portability,high robustness,miniaturization,low cost,no pretreatment and rapid detection.Firstly,the components of SARS-CoV-2,the causative bacterium of COVID-19 are roughly described in this paper.Secondly,the researches on three electrochemical biosensors that can specifically detect SARA-CoV-2 based on the spike protein on the surface,internal nucleocapsid protein and ribonucleic acid(RNA) are reviewed.Moreover,the key parameters such as limit of detection,time and dynamic detection range of the three types of electrochemical biosensors are comprehensively analyzed. Meanwhile,the advantages and disadvantages of electrochemical biosensors are analyzed when compared with other methods for SARA-CoV-2 detection.Finally,it is pointed out that the improvement of electrochemical biosensor performance could be realized in the future by optimizing detection electrode materials,reaction conditions and modification detection probes,which is of important significance for early detection,early isolation and early treatment of COVID-19 patients,and even providing a strong support for the design of rapid diagnosis of COVID-19 equipment.
Key Words:severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)  electrochemical biosensor  spike protein  nucleocapsid protein  ribonucleic acid(RNA)  COVID-19
引用本文:窦雪晨,王冠,张宁,程智,杜耀华,田丰.检测SARS-CoV-2的电化学生物传感器研究进展[J].分析测试学报,2022,41(7):1090-1101.
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