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重金属的生物体原位成像技术研究进展
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作者单位
裴诚诚,聂亚光,赵亚楠,倪珅瑶,许安 1. 安徽大学 物质科学与信息技术研究院安徽 合肥 230601 2. 环境毒理与污染控制技术安徽省重点实验室中国科学院合肥物质科学研究院强磁场科学中心安徽 合肥 230031 
基金项目:国家自然科学基金项目(91743106);安徽省重点研究与开发计划项目(202004i07020015)
中文摘要:重金属广泛存在于自然环境中,由于其具有高毒性和不同的赋存形式,且在环境中不能被微生物分解,因此重金属在通过多种途径进入生物体后,极易产生累积并造成伤害。重金属在生物体内分布及形态的差异是决定其生物效应的核心因素,因此了解这些关键信息是探索其毒性机制的基础。原位成像技术能在空间上识别生物体内重金属,并直观地评价生物体内重金属的含量、分布、形态转化及摄入和排出等状态和过程,因而受到广泛关注。该文总结了激光烧蚀电感耦合等离子体质谱法(LA-ICP-MS)、同步辐射以及金属感测荧光团成像等重金属原位成像方法的基本原理和应用,比较了其各自的技术特点和应用场景,并对重金属的生物原位成像技术发展进行了展望。
中文关键词:重金属  原位成像技术  激光烧蚀电感耦合等离子体质谱  同步辐射  金属感测荧光团
 
Progress on In Situ Imaging of Heavy Metals in Living Organisms
Abstract:Heavy metals are ubiquitously present in the natural environment.Due to their high toxicity,different occurrences and resistance to microorganism decomposition,they are highly prone to accumulate and cause harm when they enter into living organisms through various pathways.The differences in the distribution and occurrence of heavy metals in organisms are the key factors that determine their biological effects,thus understanding these key factors is the basis for exploring their toxicological mechanisms.In-situ imaging technology has received widespread attention as it is designed to spatially identify heavy metals in organisms,which enables the visual evaluation of heavy metal content,distribution,transformation,as well as intake and excretion.The basic principles and applications of in-situ imaging methods for heavy metals are summarized in this paper,including laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS),synchrotron radiation and metal sensing fluorophore imaging,and their respective technical characteristics and application scenarios are compared.The perspectives on future development of in-situ imaging of heavy metals in living organisms are also provided.
Key Words:heavy metals  in-situ imaging technology  laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS)  synchrotron radiation  metal sensing fluorophore
引用本文:裴诚诚,聂亚光,赵亚楠,倪珅瑶,许安.重金属的生物体原位成像技术研究进展[J].分析测试学报,2022,41(7):1102-1110.
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