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成组毒理学分析仪在污染物识别与毒性测试中的应用
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作者单位
杨晓溪,李姿慷,郭云鹤,刘艳娜,王易,聂童,周群芳,史建波,曲广波,江桂斌 中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京 100085 
基金项目:国家自然科学基金资助项目(22193050,21906180,92143301,92043302)
中文摘要:成组毒理学分析仪(Integrated toxicology analyzer,ITA)是我国自主研制的国际上首套具备化学分析与毒理学评价在线测试功能的新仪器系统。该系统是以高通量多靶点毒性测试及复杂污染物在线分离鉴定为核心,实现复杂介质样品毒性效应综合评估及目标污染物鉴定的通用技术平台。ITA系统通过多种自动化设备的连接与耦合,形成了复杂样品分离与制备、效应物质结构鉴定、多靶点毒性效应评价及数据一体化分析多个功能区,可完成复杂样品的高通量自动化前处理、组分分离、毒性测试与结构解析,显著提高了污染物筛查的可靠性和效率。ITA应用范围广泛,已服务于我国环境保护、食品安全、国家安全等各个领域。该文总结了ITA在环境与健康研究中污染物识别与毒性测试方面的应用进展,并对其未来发展及应用前景进行了展望。
中文关键词:成组毒理学分析仪  高通量  自动化  复杂样品  毒性测试  污染物识别
 
Application of Integrated Toxicology Analyzer in Pollutants Identification and Toxicity Analysis
Abstract:Integrated toxicology analyzer(ITA) is the first instrument system with the functions of online chemical analysis and toxicological evaluation in the world,which is independently developed by China.This system focuses on multi-target biological effect assessment and automatic separation or identification for toxicity directed pollutants,allowing toxic effect evaluation and identification of key substances in real sample.ITA is composed of four functional areas including sample separation and preparation,chemical identification,biological effect assessment,and comprehensive data analysis via integrating multiple automatic instruments,enabling the pretreatment,fractionation,toxicity testing and chemical structure analysis for complex sample with a high-throughput and automatic manner,and significantly improving the reliability and efficiency.ITA could be widely applied in various fields where it has served as an important technical support for environment protection,food safety and national security in China.Development of ITA and its applications in pollutants identification and toxicity screening are summarized in this paper.Furthermore,the future development and potential applications of ITA are anticipated.
Key Words:integrated toxicology analyzer  high-throughput  automatization  complex sample  toxicity analysis  pollutants identification
引用本文:杨晓溪,李姿慷,郭云鹤,刘艳娜,王易,聂童,周群芳,史建波,曲广波,江桂斌.成组毒理学分析仪在污染物识别与毒性测试中的应用[J].分析测试学报,2022,41(9):1279-1285.
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