| 氧化铈在生物分析与传感检测中的应用研究进展 |
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| 基金项目:江苏省重点研发计划项目（BE2019716）；国家自然科学基金项目（82061148012，82027806，91753106） |
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| 中文摘要:铈是镧系元素中活性最高的一种稀土元素，氧化铈已广泛应用于抛光剂、脱色剂、催化剂、发光增强剂等领域。Ce3+/Ce4+之间自发的氧化还原循环可在氧化铈晶面上产生许多氧空位（V?），加快反应中的电荷转移，使氧化铈具有很高的催化活性和储放氧能力。混合价态自发的氧化还原循环以及由此产生的氧空位对氧化铈的性质有着重大影响，使其表现出独特的抗菌、抗炎、抗肿瘤和模拟酶等生物医学活性，可用于多种疾病的诊疗。此外，氧化铈还可单独使用或与其他材料掺杂、复合来构建灵敏的传感材料，应用于多种物质的分析与检测，并已成为国内外研究的热点。该文首先阐明了氧化铈作为传感材料的理论基础，然后分别从电化学传感、比色传感、荧光传感和化学发光传感四个方面对国内外氧化铈传感检测领域的应用进展进行了归纳，最后对氧化铈传感器的研发现状进行总结并对未来发展进行了展望，为高性能传感器的研发提供了参考。 |
| 中文关键词:铈 氧化铈 传感器 电化学 比色 荧光 化学发光 |
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| Research Progress on Bioanalytical and Sensing Applications of Cerium Oxide |
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| Abstract:Cerium is one of the most active rare earth elements in the lanthanide family，and cerium oxide has been widely used in fields of polisher，decolorizer，catalyst and luminescence enhancer，etc．The spontaneous redox cycle between Ce3+/Ce4+ may generate many oxygen vacancies（V?） on the cerium oxide crystal surface，which can accelerate the charge transfer in the reaction and make cerium oxide have high catalytic activity and oxygen storage and release capacity．The mixed-valence spontaneous redox cycle and the resulting oxygen vacancies have a significant impact on the properties of cerium oxide，allowing it to exhibit unique biomedical activities such as antibacterial，anti-inflammatory，anti-tumor and enzyme mimicking activities，which could be used in the treatment of many diseases．In addition，cerium oxide could be used alone or doped and compounded with other materials to build sensitive sensing materials for the analysis and detection of a variety of substances，which has become a hot spot for domestic and international research．In this review，the theoretical basis of cerium oxide as a sensing material is firstly clarified，while the research progresses of cerium oxide sensing in the fields of electrochemical sensing，colorimetric sensing，fluorescence sensing and chemiluminescence sensing at home and abroad are then summarized，and finally，the status of research and development of cerium oxide sensors are summarized，and an outlook for the future development of high-performance sensors is provided. |
| Key Words:cerium ceria sensor electrochemical colorimetric fluorescent chemiluminescent |
| 引用本文：李金成，陈芸，赖向东，刘晓辉，姜晖，王雪梅.氧化铈在生物分析与传感检测中的应用研究进展[J].分析测试学报,2022,41(9):1375-1386. |
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