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拉曼光谱检测手性化合物研究进展
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作者单位
李丹,胡瑞琪,李攻科,夏凌 中山大学 化学学院广东 广州 510006 
基金项目:国家自然科学基金重点项目(22134007);国家自然科学基金项目(21976213,22076223);广东省食品安全重点领域研发计划(2019B020211001);国家重点研发计划项目(2019YFC1606101);大学生创新训练项目(202210400)
中文摘要:手性化合物的结构和理化性质相似,但其在生物体内的药效作用或毒性程度有很大差异,误用可能造成严重危害,因此发展高效、准确的手性化合物检测技术十分重要。然而传统的检测方法不仅繁琐、耗时,而且难以检测复杂体系中的手性化合物,限制了手性化学的发展。拉曼光谱作为一种强大的表界面分析技术,不仅能提供化合物丰富的结构信息,而且具有无损和快速检测等优点,在手性化合物的检测中显现出广阔的应用前景。该文综述了近年来拉曼光谱检测手性化合物的研究进展,包括拉曼光学活性光谱、对映选择性拉曼光谱、低频拉曼光谱和表面增强拉曼散射光谱。最后提出了亟需解决的问题和未来的发展趋势。
中文关键词:拉曼光谱  手性化合物  研究进展
 
Progress in Raman Spectroscopy for Chiral Compounds Detection
Abstract:The structures and physicochemical properties of chiral compounds are similar,but their pharmacological effects or toxicity levels in living species are quite different,and their improper usage might hurt humans greatly.As a result,developing an effective and precise approach for chiral compounds detection is critical.However,traditional detection methods are tedious,time-consuming,and difficult to identify chiral compounds in complex systems,which severely limit the progress of chiral chemistry.Raman spectroscopy,as a powerful surface-interface analysis technique,could not only provide rich structural information of compounds,but also have the advantages of nondestructive and rapid detection,showing a broad application prospect in the detection of chiral compounds.In this paper,recent development of Raman spectroscopy in the detection of chiral compounds is reviewed,including Raman photoactivity spectroscopy,enantioselective Raman spectroscopy,low frequency Raman spectroscopy,and surface-enhanced Raman scattering spectroscopy.Finally,the problems that need to be solved urgently are presented,and the development trend is foreseen.
Key Words:Raman spectrum  chiral compounds  research progress
引用本文:李丹,胡瑞琪,李攻科,夏凌.拉曼光谱检测手性化合物研究进展[J].分析测试学报,2022,41(9):1431-1438.
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