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| Research Progress on Magnetic Relaxation Switches Based on Superparamagnetic Nanoparticle and Their Applications in Biochemical Analysis |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:superparamagnetic particle（SMP） magnetic relaxation switches（MRS） nano biological sensing biochemical analysis |
| Author | Institution |
| 陈翊平，邹明强，王大宁,谢孟峡,王燕飞，薛强，李锦丰 |
1.中国检验检疫科学研究院;2.北京师范大学分析测试中心 |
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| Abstract: |
| The magnetic relaxation switches（MRS）technology based on superparamagnetic nanoparticles（SMP） and their applications in biochemical analysis were introduced in this paper.In homogenous magnetic field of miniaturized nuclear magnetic,the dispersed and aggregated states of SMP produce local inhomogeneities in the applied magnetic field,resulting in the decrease or increase in the spin ± spin relaxation time（T2） of surrounding water molecules,which is called magnetic relaxation time（MRS） sensing effect.The magnetic particles binding with specific molecules can act as magnetic relaxation switches（MRS） when they coupled specially with target analytes.In MRS assays,the presence of an analyte causes the particles to transition between dispersed and clustered states and affects the T2 relaxation times of surrounding water molecules.Compared with the conventional immunological methods,MRS assay is more sensitive,simple and time-saving due to its combination of nanobiotechnology,nuclear magnetic resonance and immunoassay.Predictably,it has a remarkable application potential in the fields of medical diagnosis,environmental monitoring,food safety analysis,public healthy security and molecular interactions study,etc. |
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