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| Simultaneous Determination of Triclosan and Triclocarban in Daily Chemical Products by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) triclosan triclocarban daily chemical products |
| Author | Institution |
| 刘湘军，赵妍，赵珊，杨奕,张晶,邱细敏，邵兵 |
1.湖南师范大学医学院;2.北京市预防医学研究中心;3.南京市产品质量监督检验院 |
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| Abstract: |
| An ultra performance liquid chromatography-tandem mass spectrometric(UPLC-MS/MS) method was developed for the simultaneous determination of triclosan and triclocarban in daily chemical products,including toothpaste,hand sanitizer,disinfectant,shampoo and soap.The samples were ultrasonically extracted with organic solvents and centrifugated.The analytes were separated on an ACQUITY UPLC HSS T3 column,and identified under negative electrospray ionization(ESI-) and multiple reaction monitoring(MRM) mode.The standard calibration curves were used for the quantitative analysis.Good linearities were achieved for triclosan and triclocarban over the ranges of 1-250 μg/L and 0.2-50 μg/L,respectively,with correlation coefficients(r2) more than 0.995.The quantitation limits of the method were in the ranges of 0.2-0.7 mg/kg for triclosan and 0.01-0.02 mg/kg for triclocarban.Mean recoveries of the two target compounds in five kinds of daily chemical products at three spiked concentration levels ranged from 86% to 116% with relative standard deviations(RSDs) no more than 15%.This method could be applied in the simultaneous determination of triclosan and triclocarban in daily chemical products. |
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