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| Enantiomeric Separation and Optical Purity Analysis of Eight Aromatic Alcohol by Capillary Zone Electrophoresis |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:aromatic alcohol mono-6-ammonium-6-deoxy-β-cyclodextrin chloride chiral separation optical purity capillary electrophoresis |
| Author | Institution |
| 王玉,王彤,韩泳,聂慧芳,李晰,赵燕 |
1.第四军医大学药学院;2.沈阳药科大学药学院 |
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| Abstract: |
| A method of capillary electrophoresis(CE) was developed for the analyisi of the optical purity of eight aromatic alcohols with different substituent groups using mono-6-ammonium-6-deoxy-β-cyclodextrin chloride(β-CD-NH3Cl) as chiral selector.The separation conditions were optimized through investigation of effects of concentration of β-CD-NH3Cl and background electrolyte,pH value of buffer,running voltage,etc.Under the optimized conditions,the eight samples of aromatic alcohol were successfully separated.The optical purities of the eight aromatic alcohol enantiomers were investigated by CE method,and the results were evaluated by comparion with those obtained by the HPLC method.The results showed that the enantiomers excesses(e.e%) of three batches of samples determined by CE were consistent with those by HPLC.This method is simple and accurate,and could be applied in the chiral separation of eight aromatic alcohol enantiomers and the determination of e.e%. |
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