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| Indirect Determination of Anisaldehyde Dimethyl Acetal in the Process of Electrochemical Oxidation Synthesis by HPLC |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:HPLC electrochemical oxidation synthesis anisaldehyde dimethyl acetal anisaldehyde indirect determination |
| Author | Institution |
| 周巧玲，王明，徐颖华，马淳安，刘文涵 |
浙江工业大学化学工程与材料/绿色化学合成技术国家重点实验室培育基地 |
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| Abstract: |
| The anisaldehyde dimethyl acetal （p-MBDMA） that produced by direct electrochemical oxidation synthesis in the anhydrous KF-CH3OH system is easily hydrolyzed in water.The study results indicated that p-MBDMA could be hydrolyzed into anisaldehyde raidly and completely in the acidic mixed solution of methanol，acetonitrile and water.Based on this，a high performance liquid chromatographic （HPLC） method was developed for the determination of p-MBDMA indirectly.The best mobile phase was a mixture of water-methanol-acetonitrile（50∶30∶20，adjusted pH 3.0 by phosphoric acid）.The internal mechanism of p-MBDMA in the column was also investigated.The results showed that HPLC method could be successfully applied in the rapid determination of p-MBDMA content. |
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