Simultaneous Determination of 3 Sulfonylureas in Cosmetics by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry
  
View Full Text    Download reader
DOI:10.3969/j.issn.1004-4957.年份.月份
KeyWord:ultra-performance liquid chromatography-tandem mass spectrometry  cosmetics  carbutamide  chlorpropamide  tolbutamide
  
AuthorInstitution
周莉莉,王艳丽,杨颖,薛霞,杨昊,刘桂亮,郑红,张艳侠,卢兰香 山东省产品质量监督检验研究院国家加工食品质量监督检验中心(山东)
Hits: 2791
Download times: 1126
Abstract:
      A comprehensive ultra performance liquid chromatography-tandem mass spectrometric(UPLC-MS/MS)method was developed for the determination of 3 sulfonylureas(carbutamide,chlorpropamide and tolbutamide)in cosmetics.Various cosmetic samples,including cream,aqua and ointment,were extracted with acidified methanol and then diluted with water.The extract was separated with reversed-phase UPLC using a binary eluent under isocratic conditions,and determined by MS/MS under the negative electrospray ionization mode with multiple reaction monitoring.The result indicated that a good separation of three compounds was obtained in 5 min.The calibration curves for 3 sulfonylureas were linear in the range of 0.001-0.1 mg/L with correlation coefficients more than 0.999.The limits of quantitation(LOQs)for 3 sulfonylureas were all 0.08 mg/kg.The mean recoveries at three spiked levels ranged from 80.9% to 117.0% with relative standard deviations(n=6) of 3.6%-97%.Under the optimal conditions,The method has good simplicity,sensitivity and stability,and is suitable for the rapid determination of 3 sulfonylureas in cosmetics.
Close