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| Simultaneous Analysis of Analeptics and Their Metabolites by Liquid Chromatography-Electrospray Ion Trap Mass Spectrometry |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:toxicological analysis liquid chromatography-electrospray ion trap mass spectrometry（LC-ESI-ITMS） mouse liver S9 fractions analeptic in-vitro metabolism |
| Author | Institution |
| 陈学国，宋鸣，朱昱，吴迪，许英健 |
1.中国刑事警察学院法医系;2.辽宁省公安厅刑事科学技术研究所 |
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| Abstract: |
| A liquid chromatography-electrospray ionization-ion trap mass spectrometric（LC-ESI-ITMS） method was develop for the simultaneous analysis of three common analeptics and their in-vitro metabolites.Analeptics were incubated individually with mouse liver microsome S9 fraction firstly，and then the incubation samples were pooled together and analyzed by LC-ESI-ITMS in full-scan mode.Analeptics and their metabolites were identified from the determination of molecular ions.The metabolites detection were confirmed from tandem mass spectrometric（MSn） analysis.With the advanteges of rapidness，high accuracy，good selectivity and sensitivity，the method was suitable for the analysis of three common analeptics and their in-vitro metabolites. |
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