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| Determination of Tocopherols and α-Tocopheryl Acetate in Cosmetics by Supercritical Fluid Chromatography |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:supercritical fluid chromatography(SFC) cosmetics tocopherol α-tocopheryl acetate |
| Author | Institution |
| LI Hui-yong,XI Shao-feng,TAN Jian-hua*,WANG Ji-cai,XIONG Xiao-ting,ZHAO Tian-tian,WU Chu-sen,GUO Chang-hong |
1.广州市质量监督检测研究院国家化妆品质量监督检验中心广州;2.华南农业大学资源环境学院 |
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| Abstract: |
| A supercritical fluid chromatographic(SFC) method was developed for the determination of tocopherols and α-tocopheryl acetate in cosmetics.Different types of samples were sequentialy dispersed and extracted with acetonitrile water solution-hexane based on matix types.The chromatographic separation was conducted with a XBridge(Viridis@BEH,250 mm×4.6 mm,5 μm) by gradient elution using CO2 as mobile phase and 2-propanol∶hexane(1∶1) as modifier.The detection was performed with a photodiode-array(PDA) detector.The extraction procedures and chromatographic conditions were optimized.The results showed that the limits of quantitation(LOQ,S/N=10) were 50 mg/kg for four tocopherols and 25 mg/kg for α-tocopheryl acetate.The average recoveries ranged from 81.3% to 109.5% with relative standard deviations(RSDs) not more than 12.8%.The method is simple,rapid and accurate,and is suitable for the determination of four tocopherols and α-tocopheryl acetate in cosmetics. |
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