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| Determination of Methimazole Using Gold Nanoparticles Catalyzed Luminol Chemiluminescence System |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:methimazole chemiluminescence gold nanoparticles |
| Author | Institution |
| MU Miao*，ZHANG Yan-tu，QI Guang-cai，LIU Zhen-ye |
1.榆林学院化学与化工学院;2.延安大学化学与化工学院 |
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| Abstract: |
| A novel method for the determination of methimazole was proposed,based on its enhancement effect on the luminol-silver nitrate-gold nanoparticles（AuNPs） chemiluminescence（CL） system in alkaline medium.The experimental conditions were studied.Under the optimal experimental conditions,methimazole could be detected in 3 sectional linear ranges of 1.0×10-9-1.0×10-8,1.0×10-8-1.0×10-7，1.0×10-7-1.0×10-6 g/mL with a detection limit of 3.0×10-10g/mL,and relative standard deviation was 1.2%（n=11，ρ=1.0×10-8 g/mL）.The method was successfully applied in the determination of methimazole in pharmaceutical formulations.In addition,the mechanism of gold nanoparticles-luminol-AgNO3 system was also explored by the CL spectrum. |
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