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| Simultaneous Determination of Eight Kinds of Drug Residues in Sprouts by High Performance Liquid Chromatography-Tandem Mass Spectrometry |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:high performance liquid chromatography-tandem mass spectrometry(LC-MS/MS) sprouts drug residues |
| Author | Institution |
| ZHANG Ya-lian，LIU Han，WANG Sui-lou*，DING Tao*，XU Niu-sheng，YU Ke-yao，SHEN Wei-jian，ZHAO Zeng-yun，LIU Yun，WU Bin，ZHANG Rui，SHEN Chong-yu |
1.中国药科大学药学院;2.江苏出入境检验检疫局;3.赛默飞世尔科技色谱质谱部 |
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| Abstract: |
| A high performance liquid chromatography-tandem mass spectrometric(LC-MS/MS) method was developed for the determination of eight kinds of drugs(4-chlorophenoxyacetic acid，indole-3-acetic acid，2,4-dichlorophenoxyacetic acid，indole-3-butyric acid，1-naphthlcetic acid，gibberellin acid，6-benzylaminopurine and carbendazim) in sprouts.The samples were extracted with acetonitrile containing 0.1% acetic acid，concentrated and cleaned up with dispersive solid phase extraction powder.The extract was analyzed by LC-MS/MS.The linear ranges of eight compounds ranged from 5 μg/L to 100 μg/L with correlation coefficients(r2) more than 0.99.The limits of quantitation of eight compounds were 5 μg/kg.At three spiked concentration levels of 5，10，20 μg/kg，the recoveries of eight compounds ranged from 71.6% to 87.9% with relative standard deviations(RSDs) not more than 14.6%.The method was accurate，simple and quick，and was suitable for the simultaneous determination of eight compound residues in sprouts. |
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