|
| Determination of Five Preservatives in Cosmetics by Fully Automated Quantitative Micellar Electrokinetic Capillary Chromatography |
| |
| View Full Text Download reader |
| DOI： |
| KeyWord:quantitative capillary electrophoresis nano-valve automation electric decoupler quantitative micellar electrokinetic chromatography(qMEKC) preservatives |
| Author | Institution |
| XU Yuan,LING Bang-zan,YAO Dong,ZHANG Lin,WANG Yan,YAN Chao* |
1.上海交通大学药学院;2.上海通微分析技术有限公司 |
|
| Hits: 2466 |
| Download times: 1162 |
| Abstract: |
| A fully automatic quantitative capillary electrophoresis system,which consists of a lab-made auto-sampler equipped with a 10 nL rotary type injector and a lab-made thermostat with cooling capacity,was developed.The accuracy and precision of the method were greatly improved compared with that of the conventional capillary electrophoresis（CE）.This article explored the feasibility of determination of benzoic acid,methyl p-hydroxybenzoate（MP）,ethyl p-hydroxybenzoate（EP）,propyl p-hydroxybenzoate（PP） and butyl p-hydroxybenzoate（BP） in cosmetics by fully automated quantitative micellar electrokinetic capillary chromatography（qMEKC）.The contents of MP,benzoic acid,EP,PP and BP in body cream and exfoliating gel were determined with a mobile phase of 15 mmol/L borax buffer and 100 mmol/L SDS（pH 9.3） mixture and a separation voltage of 20 kV.Good separation for the five preservatives was achieved under the optimal conditions,with RSDs of peak area lower than 2%.This method is rapid and accurate,and may be employed in the quality control of preservatives in cosmetics. |
| Close |
|
|
|