Simultaneous Determination of Nine Fluorescent Whitening Agents in Skincare Water Using Ultrasound assisted Dispersive Liquid-Liquid Microextraction Coupled with High Performance Liquid Chromatography
  
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KeyWord:dispersive liquid-liquid microextration(DLLME)  ultrasound assisted(UA)  high performance liquid chromatography(HPLC)  fluorescent whitening agents(FWAs)  skincare water
  
AuthorInstitution
ZHANG Xian-chen*,HUA Hong-bo,BO Yan-na,LI Rong,ZHANG Peng-jie,YANG Fang,WANG Yong,XIONG Ren-guang 1.中山出入境检验检疫局检验检疫技术中心;2.中山市卓雅外国语学校;3.暨南大学包装工程研究所,广东普通高校产品包装与物流重点实验室
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Abstract:
      A method based on ultrasonic assisted dispersive emulsion microextraction procedure coupled to high performance liquid chromatography with fluorescence detector(UA-DLLME-HPLC-FLD) was developed for the determination of nine fluorescent whitening agents (FWAs) residues in skincare water.Experimental conditions affecting the microextraction procedure such as type and volume of extraction solvent,content of disperse solvent,salt concentration,pH value,extraction time and centrifugal time were investigated.The ultrasonic assisted disperse emulsion microextraction conditions were optimized by using 50 μL chloroform as solvent and 250 μL methanol as disperser solvent,and the mixture was centrifuged at 4 500 r/min for 2 min.Under the optimum conditions,the calibration curves of nine fluorescent whitening agents in a certain concentration range with correlation coefficients more than 0.999 0.The limits of detection(LODs) of night fluorescent whitening agents ranged from 0.06 mg/kg to 4.20 mg/kg and the limits of quantitation(LOQs) ranged from 0.2 mg/kg to 14.0 mg/kg.The average recoveries for nine fluorescent whitening agents residues in skincare water were in the range of 84.3%-102.4%.Compared to the previous methods,the new procedure has the characteristics of simple sample preparation,low organic solvent consumption and high sensitivity.
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